OBJECTIVE: BK virus infection after transplantation is known to cause graft failure but the association with malignancies is controversial. METHODS: BK virus workup was performed for kidney recipients in our center under conditions of hematuria or acute deterioration of graft function. We reviewed the history and reported our treatment and the disease course of three patients with BK virus later diagnosed with urothelial carcinoma. RESULTS: All three patients received kidneys from China with immunosuppression using a calcineurin inhibitor and monoclonal antibodies. Synchronous bladder and upper-tract tumors were treated with surgery followed by intravesical chemotherapies. We tapered the immunosuppressants and changed to a sirolimus-based regimen. Intravesical chemotherapy and concurrent chemoradiotherapy were performed to prevent recurrence. All three patients now have functional grafts. CONCLUSION: BK virus infection may lead to tumorigenesis. Besides decreasing immunosuppressants, we should be more alert to the detection of malignancies in BK virus-reactivated recipients. Early aggressive treatment may be curative, preserving functional grafts.
OBJECTIVE: BK virus infection after transplantation is known to cause graft failure but the association with malignancies is controversial. METHODS:BK virus workup was performed for kidney recipients in our center under conditions of hematuria or acute deterioration of graft function. We reviewed the history and reported our treatment and the disease course of three patients with BK virus later diagnosed with urothelial carcinoma. RESULTS: All three patients received kidneys from China with immunosuppression using a calcineurin inhibitor and monoclonal antibodies. Synchronous bladder and upper-tract tumors were treated with surgery followed by intravesical chemotherapies. We tapered the immunosuppressants and changed to a sirolimus-based regimen. Intravesical chemotherapy and concurrent chemoradiotherapy were performed to prevent recurrence. All three patients now have functional grafts. CONCLUSION: BK virus infection may lead to tumorigenesis. Besides decreasing immunosuppressants, we should be more alert to the detection of malignancies in BK virus-reactivated recipients. Early aggressive treatment may be curative, preserving functional grafts.
Authors: Elena Anzivino; Maria Antonella Zingaropoli; Marco Iannetta; Valeria Antonietta Pietropaolo; Alessandra Oliva; Francesco Iori; Antonio Ciardi; Donatella Maria Rodio; Francesca Antonini; Cesare Giovanni Fedele; Alessandra D'Abramo; Claudio Maria Mastroianni; Vincenzo Vullo; Maria Rosa Ciardi Journal: Cancer Genomics Proteomics Date: 2016 11-12 Impact factor: 4.069
Authors: Valerie Neirynck; Kathleen Claes; Maarten Naesens; Liesbeth De Wever; Jacques Pirenne; Dirk Kuypers; Yves Vanrenterghem; Hendrik Van Poppel; Andre Kabanda; Evelyne Lerut Journal: Case Rep Nephrol Urol Date: 2012-09-05
Authors: Darlene Vigil; Nikifor K Konstantinov; Marc Barry; Antonia M Harford; Karen S Servilla; Young Ho Kim; Yijuan Sun; Kavitha Ganta; Antonios H Tzamaloukas Journal: World J Transplant Date: 2016-09-24