| Literature DB >> 19249250 |
Richard G Hibbert1, Francesca Mattiroli, Titia K Sixma.
Abstract
Ubiquitin conjugation plays critical roles in virtually all DNA repair pathways. This review provides an overview of the known multi-domain RING/Ubox E3 ligases and their domain structures. An analysis of known RING/Ubox X-ray and NMR structures leads to a discussion of the effects of dimerization. Structural and mechanistic data relating to the E3 ligase preferences for E2 interaction and chain-type specificity are reviewed and the role of the E3 ligases in regulation of the repair pathways is discussed.Mesh：
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Year: 2009 PMID： 19249250 DOI： 10.1016/j.dnarep.2009.01.014
Source DB: PubMed Journal: DNA Repair (Amst) ISSN： 1568-7856