| Literature DB >> 19249204 |
James R Fuchs1, Bulbul Pandit, Deepak Bhasin, Jonathan P Etter, Nicholas Regan, Dalia Abdelhamid, Chenglong Li, Jiayuh Lin, Pui-Kai Li.
Abstract
Two series of curcumin analogues, a total of twenty-four compounds, were synthesized and evaluated. The most potent compound, compound 23, showed potent growth inhibitory activities on both prostate and breast cancer lines with IC(50) values in sub-micromolar range, fifty times more potent than curcumin. Curcumin analogues might be potential anti-tumor agents for breast and prostate cancers.Entities:
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Year: 2009 PMID： 19249204 DOI： 10.1016/j.bmcl.2009.01.104
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823