BACKGROUND: Acne inversa is a chronic inflammatory disorder of apocrine gland-bearing skin. The role of the innate immune system in the pathogenesis of the disease is controversial. OBJECTIVES: We investigated the expression of antimicrobial peptide/proteins in acne inversa. METHODS: Tissue samples were obtained from patients with acne inversa and compared with normal-appearing skin. The expression of psoriasin and human beta-defensin (hBD)-2 on messenger RNA and protein level was analyzed. RESULTS: Both messenger RNA and protein levels of psoriasin and hBD-2 were significantly increased in acne inversa. Macrophages expressing hBD-2 were found in the dermis. LIMITATIONS: Small sample size is a limitation. CONCLUSIONS: Antimicrobial peptide/proteins are overexpressed in acne inversa lesions as compared with normal-appearing skin. The site of the major expression depends on the particular antimicrobial peptide/protein. Psoriasin is overexpressed in epidermal keratinocytes whereas hBD-2 is produced mainly by dermal macrophages, leaving a relative deficiency of hBD-2 in the epidermis of acne inversa lesions.
BACKGROUND: Acne inversa is a chronic inflammatory disorder of apocrine gland-bearing skin. The role of the innate immune system in the pathogenesis of the disease is controversial. OBJECTIVES: We investigated the expression of antimicrobial peptide/proteins in acne inversa. METHODS: Tissue samples were obtained from patients with acne inversa and compared with normal-appearing skin. The expression of psoriasin and humanbeta-defensin (hBD)-2 on messenger RNA and protein level was analyzed. RESULTS: Both messenger RNA and protein levels of psoriasin and hBD-2 were significantly increased in acne inversa. Macrophages expressing hBD-2 were found in the dermis. LIMITATIONS: Small sample size is a limitation. CONCLUSIONS: Antimicrobial peptide/proteins are overexpressed in acne inversa lesions as compared with normal-appearing skin. The site of the major expression depends on the particular antimicrobial peptide/protein. Psoriasin is overexpressed in epidermal keratinocytes whereas hBD-2 is produced mainly by dermal macrophages, leaving a relative deficiency of hBD-2 in the epidermis of acne inversa lesions.
Authors: Mahendra Pratap Kashyap; Jasim Khan; Rajesh Sinha; Lin Jin; Venkatram Atigadda; Jessy S Deshane; Ayesha R Ahmed; Ali Kilic; Chander Raman; M Shahid Mukhtar; Craig A Elmets; Mohammad Athar Journal: Semin Cell Dev Biol Date: 2022-02-04 Impact factor: 7.499
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Authors: A S Byrd; M L Kerns; D W Williams; J C Zarif; A Z Rosenberg; M Delsante; H Liu; C A Dillen; J P Maynard; J A Caffrey; J M Sacks; S M Milner; O Aliu; K P Broderick; L S Lew; L S Miller; S Kang; G A Okoye Journal: Br J Dermatol Date: 2018-06-29 Impact factor: 9.302
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Authors: Margaret Coates; Paula Mariottoni; David L Corcoran; Hélène Fradin Kirshner; Tarannum Jaleel; David A Brown; Stephen R Brooks; John Murray; Maria I Morasso; Amanda S MacLeod Journal: PLoS One Date: 2019-05-06 Impact factor: 3.240