OBJECTIVE: To determine placental pathology and immune response at the maternal-fetal interface in pregnancies conceived by IVF via egg donation compared with nondonor IVF pregnancies. DESIGN: Retrospective case-control study. SETTING: Academic medical center. PATIENT(S): The study population included 20 egg donor and 33 nondonor IVF pregnancies of >24 weeks' gestation. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Perinatal complications (gestational hypertension, abruption, preterm delivery, cesarean section), microscopic features indicating an immune response and trophoblast damage, and characterization of inflammatory cells using immunohistochemistry. RESULT(S): There was an increase in gestational hypertension and preterm delivery in egg donor pregnancies. Dense fibrinoid deposition in the basal plate with severe chronic deciduitis containing significantly increased numbers of T helper and natural killer cells were demonstrated in egg donor placentas. Trophoblast damage was also increased in the preterm egg donor group. CONCLUSION(S): There are significant histological and immunohistochemical differences between the placentas of egg donor and nondonor IVF pregnancies. The increased immune activity and fibrinoid deposition at the maternal-fetal interface of egg donor pregnancies could represent a host versus graft rejection-like phenomenon. Copyright 2010 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.
OBJECTIVE: To determine placental pathology and immune response at the maternal-fetal interface in pregnancies conceived by IVF via egg donation compared with nondonor IVF pregnancies. DESIGN: Retrospective case-control study. SETTING: Academic medical center. PATIENT(S): The study population included 20 egg donor and 33 nondonor IVF pregnancies of >24 weeks' gestation. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Perinatal complications (gestational hypertension, abruption, preterm delivery, cesarean section), microscopic features indicating an immune response and trophoblast damage, and characterization of inflammatory cells using immunohistochemistry. RESULT(S): There was an increase in gestational hypertension and preterm delivery in egg donor pregnancies. Dense fibrinoid deposition in the basal plate with severe chronic deciduitis containing significantly increased numbers of T helper and natural killer cells were demonstrated in egg donor placentas. Trophoblast damage was also increased in the preterm egg donor group. CONCLUSION(S): There are significant histological and immunohistochemical differences between the placentas of egg donor and nondonor IVF pregnancies. The increased immune activity and fibrinoid deposition at the maternal-fetal interface of egg donor pregnancies could represent a host versus graft rejection-like phenomenon. Copyright 2010 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.
Authors: Z Pavlovic; K C Hammer; M Raff; P Patel; K N Kunze; B Kaplan; C Coughlin; J Hirshfeld-Cytron Journal: J Assist Reprod Genet Date: 2020-03-04 Impact factor: 3.412
Authors: Kirk P Conrad; Georgia M Graham; Yueh-Yun Chi; Xiaoman Zhai; Minjie Li; R Stan Williams; Alice Rhoton-Vlasak; Mark S Segal; Charles E Wood; Maureen Keller-Wood Journal: Am J Physiol Endocrinol Metab Date: 2019-08-13 Impact factor: 4.310
Authors: Linda M Ernst; Crystal Bockoven; Alexa Freedman; Vivien Wang; Matthew Pellerite; Todd N Wylie; Kristine M Wylie Journal: Placenta Date: 2021-03-01 Impact factor: 3.481