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Literature DB >> 19248065

Polysaccharide-block-polypeptide copolymer vesicles: towards synthetic viral capsids.

Christophe Schatz¹, Stéphanie Louguet, Jean-François Le Meins, Sébastien Lecommandoux.

Abstract

Natural inspiration: Amphiphilic polysaccharide-block-polypeptide copolymers were synthesized by click chemistry from dextran end-functionalized with an alkyne group and poly(gamma-benzyl L-glutamate) end-functionalized with an azide group. The ability of these copolymers to self-assemble into small vesicles (see picture) suggests the possibility of a new generation of drug- and gene-delivery systems whose structure mimics that of viruses.

Entities: Chemical

Mesh：

Substances：

Year: 2009 PMID： 19248065 DOI： 10.1002/anie.200805895

Source DB: PubMed Journal: Angew Chem Int Ed Engl ISSN： 1433-7851 Impact factor: 15.336

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Cited

16 in total

1. Intracellular fates of cell-penetrating block copolypeptide vesicles.

Authors: Victor Z Sun; Zhibo Li; Timothy J Deming; Daniel T Kamei
Journal: Biomacromolecules Date: 2010-12-03 Impact factor: 6.988

2. Simulation and Experimental Assembly of DNA-Graft Copolymer Micelles with Controlled Morphology.

Authors: Zonghui We; Yong Ren; John-Michael Williford; Wei Qu; Kevin Huang; Shirley Ng; Hai-Quan Mao; Erik Luijten
Journal: ACS Biomater Sci Eng Date: 2015-04-07

3. Thermoresponsive and Mechanical Properties of Poly(L-proline) Gels.

Authors: Manos Gkikas; Reginald K Avery; Bradley D Olsen
Journal: Biomacromolecules Date: 2016-01-06 Impact factor: 6.988

Review 4. Polysaccharide-based nanoparticles for theranostic nanomedicine.

Authors: M Swierczewska; H S Han; K Kim; J H Park; S Lee
Journal: Adv Drug Deliv Rev Date: 2015-11-27 Impact factor: 15.470

5. Theranostic Nanoparticles with Aggregation-Induced Emission and MRI Contrast Enhancement Characteristics as a Dual-Modal Imaging Platform for Image-Guided Tumor Photodynamic Therapy.

Authors: Huikang Yang; Yufang He; Yan Wang; Li-Ming Zhang; Ruimeng Yang; Nianhua Wang; Meng Gao; Xinqing Jiang
Journal: Int J Nanomedicine Date: 2020-04-30

10. Synthesis and self-assembly of biodegradable polyethylene glycol-poly (lactic acid) diblock copolymers as polymersomes for preparation of sustained release system of doxorubicin.

Authors: Mona Alibolandi; Fatemeh Sadeghi; Seyed Hossein Sazmand; Seyed Mohammad Shahrokhi; Mahmoud Seifi; Farzin Hadizadeh
Journal: Int J Pharm Investig Date: 2015 Jul-Sep

Polysaccharide-block-polypeptide copolymer vesicles: towards synthetic viral capsids.

1. Intracellular fates of cell-penetrating block copolypeptide vesicles.

2. Simulation and Experimental Assembly of DNA-Graft Copolymer Micelles with Controlled Morphology.

3. Thermoresponsive and Mechanical Properties of Poly(L-proline) Gels.

Review 4. Polysaccharide-based nanoparticles for theranostic nanomedicine.

5. Theranostic Nanoparticles with Aggregation-Induced Emission and MRI Contrast Enhancement Characteristics as a Dual-Modal Imaging Platform for Image-Guided Tumor Photodynamic Therapy.

6. Stimulus-responsive block copolymer nano-objects and hydrogels via dynamic covalent chemistry.

7. Dextran vesicular carriers for dual encapsulation of hydrophilic and hydrophobic molecules and delivery into cells.

Review 8. Recent Progress in the Design and Medical Application of In Situ Self-Assembled Polypeptide Materials.

Review 9. Marine Polysaccharides as a Versatile Biomass for the Construction of Nano Drug Delivery Systems.

10. Synthesis and self-assembly of biodegradable polyethylene glycol-poly (lactic acid) diblock copolymers as polymersomes for preparation of sustained release system of doxorubicin.