Literature DB >> 19247674

Treatment factors associated with outcomes in children less than 3 years of age with CNS tumours.

Catherine Ward1, Kim Phipps, Carlos de Sousa, Stephen Butler, Dianne Gumley.   

Abstract

INTRODUCTION: This study aimed to document cognitive outcomes in children treated for brain tumours with surgery and/or chemotherapy before the age of 3 years and to investigate the relationship between treatment factors and cognitive outcome.
MATERIALS AND METHODS: Participants were 31 children aged 7-14 years who had been diagnosed and treated for brain tumours under the age of 3 years. Neuropsychological assessment included tests of cognitive functioning (WASI), memory (CMS) and executive functioning (BADS-C). RESULTS AND DISCUSSION: IQ and memory functioning scores were within the normal range but executive function was significantly below the expected level. Lower socio-economic status, younger age at treatment, having undergone more than one surgical intervention, motor problems and speech and language difficulties were found to be related to cognitive functioning. Although this group of children have good outcomes in terms of IQ and memory they have significant difficulties with executive functioning.
CONCLUSION: Further research in this area is needed to allow for development of appropriate support packages for those who are most at risk.

Entities:  

Mesh:

Year:  2009        PMID: 19247674     DOI: 10.1007/s00381-009-0832-8

Source DB:  PubMed          Journal:  Childs Nerv Syst        ISSN: 0256-7040            Impact factor:   1.475


  17 in total

Review 1.  Neurocognitive sequelae of childhood cancers and their treatment.

Authors:  Raymond K Mulhern; Robert W Butler
Journal:  Pediatr Rehabil       Date:  2004 Jan-Mar

2.  Long-term sequelae in children after cerebellar astrocytoma surgery.

Authors:  F K Aarsen; H R Van Dongen; P F Paquier; M Van Mourik; C E Catsman-Berrevoets
Journal:  Neurology       Date:  2004-04-27       Impact factor: 9.910

3.  Neurocognitive deficits in medulloblastoma survivors and white matter loss.

Authors:  R K Mulhern; W E Reddick; S L Palmer; J O Glass; T D Elkin; L E Kun; J Taylor; J Langston; A Gajjar
Journal:  Ann Neurol       Date:  1999-12       Impact factor: 10.422

4.  Preschoolers with language disorders: 10 years later.

Authors:  D M Aram; B L Ekelman; J E Nation
Journal:  J Speech Hear Res       Date:  1984-06

5.  Cognitive and adaptive outcome in low-grade pediatric cerebellar astrocytomas: evidence of diminished cognitive and adaptive functioning in National Collaborative Research Studies (CCG 9891/POG 9130).

Authors:  Dean W Beebe; M Douglas Ris; F Daniel Armstrong; John Fontanesi; Raymond Mulhern; Emi Holmes; Jeffrey H Wisoff
Journal:  J Clin Oncol       Date:  2005-08-01       Impact factor: 44.544

6.  Psychological adjustment of 'surgery-only' pediatric neuro-oncology patients: a retrospective analysis.

Authors:  Eugene A Meyer; Mark W Kieran
Journal:  Psychooncology       Date:  2002 Jan-Feb       Impact factor: 3.894

Review 7.  Neural plasticity and cognitive development.

Authors:  J Stiles
Journal:  Dev Neuropsychol       Date:  2000       Impact factor: 2.253

8.  Children and adolescents with chronic cerebellar lesions show no clinically relevant signs of aphasia or neglect.

Authors:  S Richter; B Schoch; O Kaiser; H Groetschel; C Hein-Kropp; M Maschke; A Dimitrova; E Gizewski; W Ziegler; H-O Karnath; D Timmann
Journal:  J Neurophysiol       Date:  2005-07-20       Impact factor: 2.714

Review 9.  Late neurocognitive sequelae in survivors of brain tumours in childhood.

Authors:  Raymond K Mulhern; Thomas E Merchant; Amar Gajjar; Wilburn E Reddick; Larry E Kun
Journal:  Lancet Oncol       Date:  2004-07       Impact factor: 41.316

10.  Late neuropsychological and behavioural outcome of children surgically treated for craniopharyngioma.

Authors:  D Riva; C Pantaleoni; M Devoti; V Saletti; F Nichelli; C Giorgi
Journal:  Childs Nerv Syst       Date:  1998 Apr-May       Impact factor: 1.475

View more
  4 in total

Review 1.  Surgical treatment of brain tumors in infants younger than six months of age and review of the literature.

Authors:  Shih-Shan Lang; Lauren A Beslow; Brandon Gabel; Alex R Judkins; Michael J Fisher; Leslie N Sutton; Phillip B Storm; Gregory G Heuer
Journal:  World Neurosurg       Date:  2011-11-07       Impact factor: 2.104

Review 2.  Central nervous system injury and neurobiobehavioral function in children with brain tumors: a review of the literature.

Authors:  Mary Baron Nelson; Peggy Compton; Sunita K Patel; Eufemia Jacob; Ronald Harper
Journal:  Cancer Nurs       Date:  2013 Mar-Apr       Impact factor: 2.592

3.  Pediatric central nervous system tumors in the first 3 years of life: pre-operative mean platelet volume, neutrophil/lymphocyte count ratio, and white blood cell count correlate with the presence of a central nervous system tumor.

Authors:  Abdulfettah Tumturk; Mehmet Akif Ozdemir; Huseyin Per; Ekrem Unal; Ahmet Kucuk; Halil Ulutabanca; Musa Karakukcu; Ozlem Canoz; Hakan Gumus; Abdulhakim Coskun; Ali Kurtsoy
Journal:  Childs Nerv Syst       Date:  2016-12-09       Impact factor: 1.475

4.  Structural brain alterations in children an average of 5 years after surgery and chemotherapy for brain tumors.

Authors:  Mary Baron Nelson; Paul M Macey; Ronald M Harper; Eufemia Jacob; Sunita K Patel; Jonathan L Finlay; Marvin D Nelson; Peggy Compton
Journal:  J Neurooncol       Date:  2014-05-16       Impact factor: 4.130

  4 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.