J H Seo1, J-M Hwang, S S Park. 1. Department of Ophthalmology, Seoul National University College of Medicine, Seoul, Korea.
Abstract
PURPOSE: To compare retinal nerve fibre layer (RNFL) thickness changes between mitochondrial DNA (mtDNA) mutations at nucleotides 11778 and 14484 in Leber's hereditary optic neuropathy (LHON) using optical coherence tomography (OCT). METHODS: Thirty LHON patients with mtDNA mutations at nucleotides 11778 or 14484 underwent full ophthalmologic examinations including Stratus OCT. Patients were divided into four groups according to disease duration (early <or=6 months, late >6 months) and mtDNA mutation type (11778 and 14484), and their RNFL thicknesses were compared. RESULTS: Average RNFL thickness in the early 11778 group was significantly greater than that in the early 14484 group (P=0.04). Average RNFL thickness in the late 11778 group was significantly less than that in the late 14484 group (P=0.02). Quadrant analysis of the superior, nasal, and inferior quadrant RNFL thickness in the late 11778 group showed more severe RNFL atrophy than in the late 14484 group (P=0.023, 0.015, 0.003, respectively). CONCLUSIONS: RNFL thickness was significantly increased in the early stage and decreased in the late stage in the 11778 group than in the 14484 group.
PURPOSE: To compare retinal nerve fibre layer (RNFL) thickness changes between mitochondrial DNA (mtDNA) mutations at nucleotides 11778 and 14484 in Leber's hereditary optic neuropathy (LHON) using optical coherence tomography (OCT). METHODS: Thirty LHON patients with mtDNA mutations at nucleotides 11778 or 14484 underwent full ophthalmologic examinations including Stratus OCT. Patients were divided into four groups according to disease duration (early <or=6 months, late >6 months) and mtDNA mutation type (11778 and 14484), and their RNFL thicknesses were compared. RESULTS: Average RNFL thickness in the early 11778 group was significantly greater than that in the early 14484 group (P=0.04). Average RNFL thickness in the late 11778 group was significantly less than that in the late 14484 group (P=0.02). Quadrant analysis of the superior, nasal, and inferior quadrant RNFL thickness in the late 11778 group showed more severe RNFL atrophy than in the late 14484 group (P=0.023, 0.015, 0.003, respectively). CONCLUSIONS: RNFL thickness was significantly increased in the early stage and decreased in the late stage in the 11778 group than in the 14484 group.
Authors: Byron L Lam; William J Feuer; Joyce C Schiffman; Vittorio Porciatti; Ruth Vandenbroucke; Potyra R Rosa; Giovanni Gregori; John Guy Journal: JAMA Ophthalmol Date: 2014-04-01 Impact factor: 7.389