| Literature DB >> 19246197 |
Jian-Chun Qin1, Ya-Mei Zhang, Jin-Ming Gao, Ming-Sheng Bai, Sheng-Xiang Yang, Hartmut Laatsch, An-Ling Zhang.
Abstract
A novel cytotoxic chlorinated azaphilone derivative named chaetomugilin D (1), together with three known metabolites, chaetomugilin A (2), chaetoglobosins A (3) and C (4), has been isolated by a bioassay-guided fractionation from the EtOAc extract of the cultures of Chaetomium globosum, an endophytic fungus found in the leaves of Ginkgo biloba. Structure of 1 was established by analyses of spectroscopic methods, including 2D-NMR experiments (COSY, NOESY, HMQC, and HMBC). Compounds 1-4 displayed significant growth inhibitory activity against the brine shrimp (Artemia salina) and Mucor miehei.Entities:
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Year: 2009 PMID： 19246197 DOI： 10.1016/j.bmcl.2009.02.025
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823