| Literature DB >> 19246195 |
Choong-Sik Chae1, Jin-Soo Park, Soon-Chun Chung, Tae-Im Kim, So-Hyoung Lee, Kyung-Mi Yoon, Jongheon Shin, Ki-Bong Oh.
Abstract
Two ink genes, inkO and inkD, responsible for the earliest steps of K252a biosynthetic pathway, from Nonomurea longicantena JCM 11136 were heterologously coexpressed in Streptomycesalbus J1074. The resultant strain accumulated compound that was purified by HPLC and studied by NMR. Coexpression of inkOD yielded chromopyrrolic acid, the key intermediate in an indolocarbazole biosynthesis.Entities:
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Year: 2009 PMID： 19246195 DOI： 10.1016/j.bmcl.2009.02.026
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823