Literature DB >> 19245659

AMPK activators--potential therapeutics for metabolic and other diseases.

G Zhou1, I K Sebhat, B B Zhang.   

Abstract

AMP-activated protein kinase (AMPK)-mediated cellular metabolic responses to tissue-specific and whole-body stimuli play a vital role in the control of energy homeostasis. As a cellular energy-sensing mechanism, AMPK activation stimulates glucose uptake and fat oxidation, while it suppresses lipogenesis and gluconeogenesis. The cumulative effects of AMPK activation lead to beneficial metabolic states in liver, muscle and other peripheral tissues that are critical in the pathogenesis of obesity, type 2 diabetes and related metabolic disorders. Activators of AMPK that target selected tissues hold potential as novel therapeutics for diseases in which altered energy metabolism contributes to aetiology.

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Year:  2009        PMID： 19245659     DOI： 10.1111/j.1748-1716.2009.01967.x

Source DB:  PubMed          Journal:  Acta Physiol (Oxf)        ISSN： 1748-1708            Impact factor:   6.311


  22 in total

1.  Activation of AMPK stimulates heme oxygenase-1 gene expression and human endothelial cell survival.

Authors:  Xiao-ming Liu; Kelly J Peyton; Ahmad R Shebib; Hong Wang; Ronald J Korthuis; William Durante
Journal:  Am J Physiol Heart Circ Physiol       Date:  2010-10-29       Impact factor: 4.733

2.  Skeletal Muscle-Specific Activation of Gq Signaling Maintains Glucose Homeostasis.

Authors:  Derek B J Bone; Jaroslawna Meister; Jonas R Knudsen; Diptadip Dattaroy; Amanda Cohen; Regina Lee; Huiyan Lu; Daniel Metzger; Thomas E Jensen; Jürgen Wess
Journal:  Diabetes       Date:  2019-04-01       Impact factor: 9.461

3.  Fluorinated N,N'-diarylureas as AMPK activators.

Authors:  Vitaliy Sviripa; Wen Zhang; Michael D Conroy; Eric S Schmidt; Alice X Liu; Johnny Truong; Chunming Liu; David S Watt
Journal:  Bioorg Med Chem Lett       Date:  2013-01-30       Impact factor: 2.823

4.  AMP-activated protein kinase (AMPK) activation regulates in vitro bone formation and bone mass.

Authors:  M Shah; B Kola; A Bataveljic; T R Arnett; B Viollet; L Saxon; M Korbonits; C Chenu
Journal:  Bone       Date:  2010-04-24       Impact factor: 4.398

5.  Emerging roles of autophagy in metabolism and metabolic disorders.

Authors:  Altea Rocchi; Congcong He
Journal:  Front Biol (Beijing)       Date:  2015-03-30

6.  Discovery of Pyridones As Oral AMPK Direct Activators.

Authors:  Olivier Mirguet; Stéphane Sautet; Catherine-Anne Clément; Jérôme Toum; Frédéric Donche; Celine Marques; Emilie Rondet; Mathieu Pizzonero; Benjamin Beaufils; Yann Dudit; Pascal Huet; Lionel Trottet; Pascal Grondin; Jean-Marie Brusq; Eric Boursier; Yannick Saintillan; Edwige Nicodeme
Journal:  ACS Med Chem Lett       Date:  2013-05-17       Impact factor: 4.345

Review 7.  Role of the energy sensor AMP-activated protein kinase in renal physiology and disease.

Authors:  Kenneth R Hallows; Peter F Mount; Núria M Pastor-Soler; David A Power
Journal:  Am J Physiol Renal Physiol       Date:  2010-02-24

Review 8.  AMPK as a potential anticancer target - friend or foe?

Authors:  Hsiao-Ching Chuang; Chih-Chien Chou; Samuel K Kulp; Ching-Shih Chen
Journal:  Curr Pharm Des       Date:  2014       Impact factor: 3.116

Review 9.  The emerging role of autophagy in the pathophysiology of diabetes mellitus.

Authors:  Claudio D Gonzalez; Myung-Shik Lee; Piero Marchetti; Massimo Pietropaolo; Roberto Towns; Maria I Vaccaro; Hirotaka Watada; John W Wiley
Journal:  Autophagy       Date:  2011-01-01       Impact factor: 16.016

10.  Does LKB1 mediate activation of hepatic AMP-protein kinase (AMPK) and sirtuin1 (SIRT1) after Roux-en-Y gastric bypass in obese rats?

Authors:  Yanhua Peng; Drew A Rideout; Steven S Rakita; William R Gower; Min You; Michel M Murr
Journal:  J Gastrointest Surg       Date:  2010-02       Impact factor: 3.452
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