Literature DB >> 19245261

Acylated iridoids with cytotoxicity from Valeriana jatamansi.

Sheng Lin1, Yun-Heng Shen, Hui-Liang Li, Xian-Wen Yang, Tao Chen, Long-Hai Lu, Zheng-Sheng Huang, Run-Hui Liu, Xi-Ke Xu, Wei-Dong Zhang, Hui Wang.   

Abstract

Thirteen new acylated iridoids, jatamanvaltrates A-M (1-13), together with nine known valepotriates (14-22), were isolated from the whole plants of Valeriana jatamansi (syn. Valeriana wallichii). The structures of these new compounds were assigned by detailed interpretation of spectroscopic data. Jatamanvaltrates D (4) and H (9) are the first examples of naturally occurring valepotriates containing an o-hydroxybenzoyloxy moiety at C-10. All isolated compounds were tested for their cytotoxicity against lung adenocarcinoma (A549), metastatic prostate cancer (PC-3M), colon cancer (HCT-8), and hepatoma (Bel7402) cell lines.

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Year:  2009        PMID： 19245261     DOI： 10.1021/np800716f

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  9 in total

1.  Three new iridoids from the roots of Valeriana jatamansi.

Authors:  Jing Xu; Yuanqiang Guo; Da-qing Jin; Peng Zhao; Ping Guo; Tohru Yamakuni; Yasushi Ohizumi
Journal:  J Nat Med       Date:  2012-02-14       Impact factor: 2.343

2.  Valeriana wallichii root extracts and fractions with activity against Leishmania spp.

Authors:  Subhalakshmi Ghosh; Sukalyani Debnath; Sudipta Hazra; Andreas Hartung; Katja Thomale; Martina Schultheis; Petra Kapkova; Uta Schurigt; Heidrun Moll; Ulrike Holzgrabe; Banasri Hazra
Journal:  Parasitol Res       Date:  2010-11-18       Impact factor: 2.289

Review 3.  Chemical Components and Cardiovascular Activities of Valeriana spp.

Authors:  Heng-Wen Chen; Ben-Jun Wei; Xuan-Hui He; Yan Liu; Jie Wang
Journal:  Evid Based Complement Alternat Med       Date:  2015-12-16       Impact factor: 2.629

4.  Studies of the structure-antioxidant activity relationships and antioxidant activity mechanism of iridoid valepotriates and their degradation products.

Authors:  Feifei Wang; Yumei Zhang; Shouhai Wu; Yi He; Zhong Dai; Shuangcheng Ma; Bin Liu
Journal:  PLoS One       Date:  2017-12-12       Impact factor: 3.240

5.  Chemical Composition and Biological Activities of Methanolic Extract of Scrophularia Oxysepala Boiss.

Authors:  Ardalan Pasdaran; Abbas Delazar; Seyed Abdulmajid Ayatollahi; Arsalan Pasdaran
Journal:  Iran J Pharm Res       Date:  2017       Impact factor: 1.696

6.  Antileishmanial and cytotoxic compounds from Valeriana wallichii and identification of a novel nepetolactone derivative.

Authors:  Jan Glaser; Martina Schultheis; Heidrun Moll; Banasri Hazra; Ulrike Holzgrabe
Journal:  Molecules       Date:  2015-04-01       Impact factor: 4.411

Review 7.  The potential of Valeriana as a traditional Chinese medicine: traditional clinical applications, bioactivities, and phytochemistry.

Authors:  Jianchun Li; Xiaoliang Li; Changfu Wang; Manli Zhang; Minhui Ye; Qiuhong Wang
Journal:  Front Pharmacol       Date:  2022-09-21       Impact factor: 5.988

8.  Differential iridoid production as revealed by a diversity panel of 84 cultivated and wild blueberry species.

Authors:  Courtney P Leisner; Mohamed O Kamileen; Megan E Conway; Sarah E O'Connor; C Robin Buell
Journal:  PLoS One       Date:  2017-06-13       Impact factor: 3.752

9.  Antidepressant effects of total iridoids of Valeriana jatamansi via the intestinal flora-blood-brain barrier pathway.

Authors:  Li Zhang; Liwen Wang; Li Huang; Yanni Zhao; Hongling Ding; Binglong Li; Lingmiao Wen; Wei Xiong; Yanjun Liu; Tinglan Zhang; Liudai Zhang; Lanlan Wu; Qing Xu; Yuqing Fan; Guihua Wei; Qiaozhi Yin; Yunhui Chen; Tiane Zhang; Zhiyong Yan
Journal:  Pharm Biol       Date:  2021-12       Impact factor: 3.503
  9 in total

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