Literature DB >> 19245260

Cottoquinazoline A and cotteslosins A and B, metabolites from an Australian marine-derived strain of Aspergillus versicolor.

Leith J Fremlin1, Andrew M Piggott, Ernest Lacey, Robert J Capon.   

Abstract

An Australian marine-derived isolate of Aspergillus versicolor (MST-MF495) yielded the known fungal metabolites sterigmatocystin, violaceol I, violaceol II, diorcinol, (-)-cyclopenol, and viridicatol, along with a new alkaloid, cottoquinazoline A (1), and two new cyclopentapeptides, cotteslosins A (2) and B (3). Structures for 1-3 and the known compounds were determined by spectroscopic analysis. The absolute configurations of 1-3 were addressed by chemical degradation and application of the C(3) Marfey's method. The use of "cellophane raft" high-nutrient media as a device for up-regulating secondary metabolite diversity in marine-derived fungi is discussed. The antibacterial properties displayed by A. versicolor (MST-MF495) were attributed to the phenols violaceol I, violaceol II, and diorcinol, while cotteslosins 2 and 3 were identified as weak cytotoxic agents.

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Year:  2009        PMID： 19245260     DOI： 10.1021/np800777f

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  38 in total

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Journal:  Mol Biosyst       Date:  2009-12-16

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4.  Comparative genomics reveals high biological diversity and specific adaptations in the industrially and medically important fungal genus Aspergillus.

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Journal:  Genome Biol       Date:  2017-02-14       Impact factor: 13.583

Review 5.  Short pathways to complexity generation: fungal peptidyl alkaloid multicyclic scaffolds from anthranilate building blocks.

Authors:  Christopher T Walsh; Stuart W Haynes; Brian D Ames; Xue Gao; Yi Tang
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Review 6.  Biologically active quinoline and quinazoline alkaloids part II.

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Journal:  Med Res Rev       Date:  2018-02-27       Impact factor: 12.944

7.  Secoemestrin D, a cytotoxic epitetrathiodioxopiperizine, and emericellenes A-E, five sesterterpenoids from Emericella sp. AST0036, a fungal endophyte of Astragalus lentiginosus1.

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Review 8.  Development of novel drugs from marine surface associated microorganisms.

Authors:  Anahit Penesyan; Staffan Kjelleberg; Suhelen Egan
Journal:  Mar Drugs       Date:  2010-03-01       Impact factor: 5.118

9.  Five sesquiterpenoids from a marine-derived fungus Aspergillus sp. isolated from a gorgonian Dichotella gemmacea.

Authors:  Mei-Yan Wei; Chang-Yun Wang; Qing-Ai Liu; Chang-Lun Shao; Zhi-Gang She; Yong-Cheng Lin
Journal:  Mar Drugs       Date:  2010-03-29       Impact factor: 5.118

10.  Complexity generation in fungal peptidyl alkaloid biosynthesis: a two-enzyme pathway to the hexacyclic MDR export pump inhibitor ardeemin.

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Journal:  ACS Chem Biol       Date:  2013-02-06       Impact factor: 5.100
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