Literature DB >> 19244319

CD4 T cells mediate killing during persistent gammaherpesvirus 68 infection.

Kathleen A Stuller1, Emilio Flaño.   

Abstract

CD4 T cells are critical for the control of gammaherpesvirus persistence, but their direct effector mechanisms of virus control in vivo are still poorly understood. In this study, we use murine gammaherpesvirus 68 (gammaHV68) in in vitro and in vivo cytotoxicity assays to show CD4-dependent killing of gammaHV68-loaded cells in mice persistently infected with gammaHV68. Our results underscore the cytotoxic capacity of CD4 T cells during gammaHV68 persistence.

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Year:  2009        PMID： 19244319      PMCID： PMC2668489          DOI： 10.1128/JVI.02240-08

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  19 in total

1.  CD4(+)CD8(dim) T lymphocytes exhibit enhanced cytokine expression, proliferation and cytotoxic activity in response to HCMV and HIV-1 antigens.

Authors:  M A Suni; S A Ghanekar; D W Houck; H T Maecker; S B Wormsley; L J Picker; R B Moss; V C Maino
Journal:  Eur J Immunol       Date:  2001-08       Impact factor: 5.532

2.  An optimized CD4 T-cell response can control productive and latent gammaherpesvirus infection.

Authors:  Rebecca L Sparks-Thissen; Douglas C Braaten; Scott Kreher; Samuel H Speck; Herbert W Virgin
Journal:  J Virol       Date:  2004-07       Impact factor: 5.103

3.  CD4 T cell control of acute and latent murine gammaherpesvirus infection requires IFNgamma.

Authors:  Rebecca L Sparks-Thissen; Douglas C Braaten; Kai Hildner; Theresa L Murphy; Kenneth M Murphy; Herbert W Virgin
Journal:  Virology       Date:  2005-08-01       Impact factor: 3.616

4.  Memory generation and maintenance of CD8+ T cell function during viral persistence.

Authors:  Stephanie S Cush; Kathleen M Anderson; David H Ravneberg; Janet L Weslow-Schmidt; Emilio Flaño
Journal:  J Immunol       Date:  2007-07-01       Impact factor: 5.422

5.  Characterization of CD4(+) CTLs ex vivo.

Authors:  Victor Appay; John J Zaunders; Laura Papagno; Julian Sutton; Angel Jaramillo; Anele Waters; Philippa Easterbrook; Pat Grey; Don Smith; Andrew J McMichael; David A Cooper; Sarah L Rowland-Jones; Anthony D Kelleher
Journal:  J Immunol       Date:  2002-06-01       Impact factor: 5.422

6.  Direct killing of Epstein-Barr virus (EBV)-infected B cells by CD4 T cells directed against the EBV lytic protein BHRF1.

Authors:  Elise Landais; Xavier Saulquin; Emmanuel Scotet; Lydie Trautmann; Marie-Alix Peyrat; John L Yates; William W Kwok; Marc Bonneville; Elisabeth Houssaint
Journal:  Blood       Date:  2003-10-16       Impact factor: 22.113

7.  Identification of circulating antigen-specific CD4+ T lymphocytes with a CCR5+, cytotoxic phenotype in an HIV-1 long-term nonprogressor and in CMV infection.

Authors:  John J Zaunders; Wayne B Dyer; Bin Wang; Mee Ling Munier; Monica Miranda-Saksena; Rebecca Newton; John Moore; Charles R Mackay; David A Cooper; Nitin K Saksena; Anthony D Kelleher
Journal:  Blood       Date:  2003-11-26       Impact factor: 22.113

8.  CD4+ T-cell responses to Epstein-Barr virus (EBV) latent-cycle antigens and the recognition of EBV-transformed lymphoblastoid cell lines.

Authors:  H M Long; T A Haigh; N H Gudgeon; A M Leen; C-W Tsang; J Brooks; E Landais; E Houssaint; S P Lee; A B Rickinson; G S Taylor
Journal:  J Virol       Date:  2005-04       Impact factor: 5.103

9.  Control of Epstein-Barr virus infection in vitro by T helper cells specific for virion glycoproteins.

Authors:  Dinesh Adhikary; Uta Behrends; Andreas Moosmann; Klaus Witter; Georg W Bornkamm; Josef Mautner
Journal:  J Exp Med       Date:  2006-03-20       Impact factor: 14.307

10.  Acquisition of direct antiviral effector functions by CMV-specific CD4+ T lymphocytes with cellular maturation.

Authors:  Joseph P Casazza; Michael R Betts; David A Price; Melissa L Precopio; Laura E Ruff; Jason M Brenchley; Brenna J Hill; Mario Roederer; Daniel C Douek; Richard A Koup
Journal:  J Exp Med       Date:  2006-12-11       Impact factor: 14.307
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  30 in total

Review 1.  Cytolytic CD4 cells: Direct mediators in infectious disease and malignancy.

Authors:  Deborah M Brown
Journal:  Cell Immunol       Date:  2010-02-24       Impact factor: 4.868

Review 2.  CD8⁺ T Cell-Independent Immune-Mediated Mechanisms of Anti-Tumor Activity.

Authors:  G Elizabeth Pluhar; Christopher A Pennell; Michael R Olin
Journal:  Crit Rev Immunol       Date:  2015       Impact factor: 2.214

3.  Functional heterogeneity in the CD4+ T cell response to murine γ-herpesvirus 68.

Authors:  Zhuting Hu; Marcia A Blackman; Kenneth M Kaye; Edward J Usherwood
Journal:  J Immunol       Date:  2015-02-06       Impact factor: 5.422

4.  Persistent gamma-herpesvirus infection induces a CD4 T cell response containing functionally distinct effector populations.

Authors:  Kathleen A Stuller; Stephanie S Cush; Emilio Flaño
Journal:  J Immunol       Date:  2010-03-05       Impact factor: 5.422

5.  Vaccination Produces CD4 T Cells with a Novel CD154-CD40-Dependent Cytolytic Mechanism.

Authors:  Rhea N Coler; Thomas Hudson; Sean Hughes; Po-Wei D Huang; Elyse A Beebe; Mark T Orr
Journal:  J Immunol       Date:  2015-08-21       Impact factor: 5.422

6.  A Human Gain-of-Function STING Mutation Causes Immunodeficiency and Gammaherpesvirus-Induced Pulmonary Fibrosis in Mice.

Authors:  Brock G Bennion; Harshad Ingle; Teresa L Ai; Cathrine A Miner; Derek J Platt; Amber M Smith; Megan T Baldridge; Jonathan J Miner
Journal:  J Virol       Date:  2019-02-05       Impact factor: 5.103

7.  CD4 T cells specific for a latency-associated γ-herpesvirus epitope are polyfunctional and cytotoxic.

Authors:  Michael L Freeman; Claire E Burkum; Tres Cookenham; Alan D Roberts; Kathleen G Lanzer; Gail E Huston; Meghan K Jensen; John Sidney; Bjoern Peters; Jacob E Kohlmeier; David L Woodland; Linda F van Dyk; Alessandro Sette; Marcia A Blackman
Journal:  J Immunol       Date:  2014-11-05       Impact factor: 5.422

8.  Emergence of simian immunodeficiency virus-specific cytotoxic CD4+ T cells and increased humoral responses correlate with control of rebounding viremia in CD8-depleted macaques infected with Rev-independent live-attenuated simian immunodeficiency virus.

Authors:  Agneta von Gegerfelt; Antonio Valentin; Candido Alicea; Koen K A Van Rompay; Marta L Marthas; David C Montefiori; George N Pavlakis; Barbara K Felber
Journal:  J Immunol       Date:  2010-08-11       Impact factor: 5.422

9.  Cytomegalovirus-Specific CD4 T Cells Are Cytolytic and Mediate Vaccine Protection.

Authors:  Shilpi Verma; Daniela Weiskopf; Ankan Gupta; Bryan McDonald; Bjoern Peters; Alessandro Sette; Chris A Benedict
Journal:  J Virol       Date:  2015-10-21       Impact factor: 5.103

Review 10.  Evasion of adaptive and innate immune response mechanisms by γ-herpesviruses.

Authors:  Pinghui Feng; Ashlee Moses; Klaus Früh
Journal:  Curr Opin Virol       Date:  2013-06-02       Impact factor: 7.090
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