D A de Luis1, M Gonzalez Sagrado, R Conde, R Aller, O Izaola, J L Perez Castrillon, A Dueñas. 1. Institute of Endocrinology and Nutrition, Medicine School and Unit of Investigation, Hospital Rio Hortega, RD-056/0013 RETICEF, University of Valladolid, C/Los perales 16, Simancas 47130, Valladolid, Spain. dadluis@yahoo.es
Abstract
BACKGROUND: The aim of the present study was to explore the relationship of resistin levels with these above mentioned factors. SUBJECTS: A population of 213 obese was analyzed. A complete nutritional and biochemical evaluation was performed. RESULTS: The mean age was 45.1+16.7 years, the mean BMI was 35.6+5.7. Higher weight, fat mass, fat free mass, waist to hip ratio, RMR, insulin and HOMA levels were observed in men than women. In all group, the analysis with a dependent variable (resistin) showed that fat mass remained in the model (F=2.48; p<0.05), with an increase of 0.033 ng/ml (CI 95%: 0.011-0.055) with each 1 kg of fat mass and a decrease of -0.29 ng/ml (CI 95%: -0.53, -0.01) with each mmHg of diastolic blood pressure. In a second model (only women) (resistin), fat mass remained in the model (F=6.06; p<0.05), with an increase of 0.037 ng/ml (CI 95%: 0.015, 0.06) with each kg of fat mass and a decrease of -0.032 ng/ml (CI 95%: -0.054, -0.01) with each mmHg of diastolic blood pressure. The third multivariate analysis (only men) did not show any relation among resistin levels and other parameters. CONCLUSION: Resistin levels are related with different cardiovascular risk and anthropometric parameters, without relation with insulin resistance. A sex interaction has been observed.
BACKGROUND: The aim of the present study was to explore the relationship of resistin levels with these above mentioned factors. SUBJECTS: A population of 213 obese was analyzed. A complete nutritional and biochemical evaluation was performed. RESULTS: The mean age was 45.1+16.7 years, the mean BMI was 35.6+5.7. Higher weight, fat mass, fat free mass, waist to hip ratio, RMR, insulin and HOMA levels were observed in men than women. In all group, the analysis with a dependent variable (resistin) showed that fat mass remained in the model (F=2.48; p<0.05), with an increase of 0.033 ng/ml (CI 95%: 0.011-0.055) with each 1 kg of fat mass and a decrease of -0.29 ng/ml (CI 95%: -0.53, -0.01) with each mmHg of diastolic blood pressure. In a second model (only women) (resistin), fat mass remained in the model (F=6.06; p<0.05), with an increase of 0.037 ng/ml (CI 95%: 0.015, 0.06) with each kg of fat mass and a decrease of -0.032 ng/ml (CI 95%: -0.054, -0.01) with each mmHg of diastolic blood pressure. The third multivariate analysis (only men) did not show any relation among resistin levels and other parameters. CONCLUSION:Resistin levels are related with different cardiovascular risk and anthropometric parameters, without relation with insulin resistance. A sex interaction has been observed.