Literature DB >> 19243699

The effect of berberine in vitro on tight junctions in human Caco-2 intestinal epithelial cells.

Lili Gu1, Ning Li, Qiurong Li, Qiang Zhang, Chengyang Wang, Weiming Zhu, Jieshou Li.   

Abstract

Berberine is one of the main alkaloids of Rhizoma coptidis which has been used for patients with gastrointestinal disorders. The major aim of this study was to investigate the effect of berberine on tight junction. Caco-2 cells were treated with various concentration of berberine. We observed the integrity of tight junction by measuring the transepithelial electrical resistance (TEER), and also studied the effect of berberine on morphology of tight junction and tight junction protein. These findings showed the first time that berberine could reduce epithelial gut permeability, and might help explain the possible mechanisms of anti-diarrhea activity of berberine.

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Year:  2009        PMID： 19243699     DOI： 10.1016/j.fitote.2009.02.005

Source DB:  PubMed          Journal:  Fitoterapia        ISSN： 0367-326X            Impact factor:   2.882


  16 in total

Review 1.  Medicinal Species of the Genus Berberis: A Review of Their Traditional and Ethnomedicinal Uses, Phytochemistry and Pharmacology.

Authors:  Zahra Sobhani; Maryam Akaberi; Mohammad Sadegh Amiri; Mahin Ramezani; Seyed Ahmad Emami; Amirhossein Sahebkar
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2.  Antinociceptive effect of berberine on visceral hypersensitivity in rats.

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Review 3.  Role of zonula occludens in gastrointestinal and liver cancers.

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Review 4.  Loss of Gut Barrier Integrity In Lupus.

Authors:  Longhuan Ma; Laurence Morel
Journal:  Front Immunol       Date:  2022-06-20       Impact factor: 8.786

5.  Sieving characteristics of cytokine- and peroxide-induced epithelial barrier leak: Inhibition by berberine.

Authors:  Katherine M DiGuilio; Christina M Mercogliano; Jillian Born; Brendan Ferraro; Julie To; Brittany Mixson; Allison Smith; Mary Carmen Valenzano; James M Mullin
Journal:  World J Gastrointest Pathophysiol       Date:  2016-05-15

6.  Amelioration of IFN-γ and TNF-α-induced intestinal epithelial barrier dysfunction by berberine via suppression of MLCK-MLC phosphorylation signaling pathway.

Authors:  Min Cao; Pei Wang; Chunhong Sun; Wen He; Fengjun Wang
Journal:  PLoS One       Date:  2013-05-03       Impact factor: 3.240

7.  Examination of the Anti-Inflammatory, Antioxidant, and Xenobiotic-Inducing Potential of Broccoli Extract and Various Essential Oils during a Mild DSS-Induced Colitis in Rats.

Authors:  Kristin Mueller; Nicole Michaela Blum; Andreas Stefan Mueller
Journal:  ISRN Gastroenterol       Date:  2013-02-28

8.  Remodeling of Tight Junctions and Enhancement of Barrier Integrity of the CACO-2 Intestinal Epithelial Cell Layer by Micronutrients.

Authors:  Mary Carmen Valenzano; Katherine DiGuilio; Joanna Mercado; Mimi Teter; Julie To; Brendan Ferraro; Brittany Mixson; Isabel Manley; Valerissa Baker; Beverley A Moore; Joshua Wertheimer; James M Mullin
Journal:  PLoS One       Date:  2015-07-30       Impact factor: 3.240

9.  Update on berberine in nonalcoholic Fatty liver disease.

Authors:  Yang Liu; Li Zhang; Haiyan Song; Guang Ji
Journal:  Evid Based Complement Alternat Med       Date:  2013-06-17       Impact factor: 2.629

Review 10.  Antibacterial and antidiarrheal activities of plant products against enterotoxinogenic Escherichia coli.

Authors:  J Daniel Dubreuil
Journal:  Toxins (Basel)       Date:  2013-11-07       Impact factor: 4.546
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