AIM: The aim of this study was to evaluate the accuracy of the activity quantification of single-photon emission computed tomography/computed tomography (SPECT-CT) (90)Y-Bremsstrahlung images and to validate the S-voxel method. METHODS: An anthropomorphic torso phantom with radioactive inserts ((90)Y) was acquired by SPECT-CT. Constant calibration factors (cps/MBq) for the quantification were evaluated, considering different volume, shape, position inside the phantom, activity concentration and background, and distance from detectors. S-voxel values (EGSnrc) were implemented in MATLAB R0086 USA software. Dose comparisons between S-voxel and the conventional Medical Internal Radiation Dose method were repeated in a group of 11 patients administered with (90)Y-DOTATATE. RESULTS: Using the appropriate calibration factors to recover the volume variability, the error about the measurement repeatability and the activity variation was within 4%. The variability of activity quantification, depending on the position in the phantom, detector distance, and background, was <10%, <5%, and <10%, respectively. The absorbed-dose values calculated by OLINDA were in agreement with the mean dose values obtained by the S-voxel method (difference, <10%). CONCLUSIONS: The results confirm that, with the hybrid SPECT-CT system, quantitative analysis of SPECT (90)Y-Bremsstrahlung images and the generation of three-dimensional dose distributions are feasible. The improved analysis of Bremsstrahlung images could have a notable clinical impact, allowing to address the dosimetric verification to patients during the course of therapy.
AIM: The aim of this study was to evaluate the accuracy of the activity quantification of single-photon emission computed tomography/computed tomography (SPECT-CT) (90)Y-Bremsstrahlung images and to validate the S-voxel method. METHODS: An anthropomorphic torso phantom with radioactive inserts ((90)Y) was acquired by SPECT-CT. Constant calibration factors (cps/MBq) for the quantification were evaluated, considering different volume, shape, position inside the phantom, activity concentration and background, and distance from detectors. S-voxel values (EGSnrc) were implemented in MATLAB R0086 USA software. Dose comparisons between S-voxel and the conventional Medical Internal Radiation Dose method were repeated in a group of 11 patients administered with (90)Y-DOTATATE. RESULTS: Using the appropriate calibration factors to recover the volume variability, the error about the measurement repeatability and the activity variation was within 4%. The variability of activity quantification, depending on the position in the phantom, detector distance, and background, was <10%, <5%, and <10%, respectively. The absorbed-dose values calculated by OLINDA were in agreement with the mean dose values obtained by the S-voxel method (difference, <10%). CONCLUSIONS: The results confirm that, with the hybrid SPECT-CT system, quantitative analysis of SPECT (90)Y-Bremsstrahlung images and the generation of three-dimensional dose distributions are feasible. The improved analysis of Bremsstrahlung images could have a notable clinical impact, allowing to address the dosimetric verification to patients during the course of therapy.
Authors: Stephan Walrand; Glenn D Flux; Mark W Konijnenberg; Roelf Valkema; Eric P Krenning; Renaud Lhommel; Stanislas Pauwels; Francois Jamar Journal: Eur J Nucl Med Mol Imaging Date: 2011-03-11 Impact factor: 9.236
Authors: Sofie Van Binnebeek; Kristof Baete; Bert Vanbilloen; Christelle Terwinghe; Michel Koole; Felix M Mottaghy; Paul M Clement; Luc Mortelmans; Karin Haustermans; Eric Van Cutsem; Alfons Verbruggen; Kris Bogaerts; Chris Verslype; Christophe M Deroose Journal: Eur J Nucl Med Mol Imaging Date: 2014-03-26 Impact factor: 9.236
Authors: Heying Duan; Mohamed H Khalaf; Valentina Ferri; Lucia Baratto; Shyam M Srinivas; Daniel Y Sze; Andrei Iagaru Journal: Eur J Nucl Med Mol Imaging Date: 2021-01-14 Impact factor: 9.236
Authors: Gerrit H van de Maat; Peter R Seevinck; Mattijs Elschot; Maarten L J Smits; Hendrik de Leeuw; Alfred D van Het Schip; Maarten A D Vente; Bernard A Zonnenberg; Hugo W A M de Jong; Marnix G E H Lam; Max A Viergever; Maurice A A J van den Bosch; Johannes F W Nijsen; Chris J G Bakker Journal: Eur Radiol Date: 2012-09-27 Impact factor: 5.315
Authors: Sara St James; Bryan Bednarz; Stanley Benedict; Jeffrey C Buchsbaum; Yuni Dewaraja; Eric Frey; Robert Hobbs; Joseph Grudzinski; Emilie Roncali; George Sgouros; Jacek Capala; Ying Xiao Journal: Int J Radiat Oncol Biol Phys Date: 2020-08-14 Impact factor: 7.038