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Literature DB >> 19242784

Absolute levels of transcripts for mitochondrial uncoupling proteins UCP2, UCP3, UCP4, and UCP5 show different patterns in rat and mice tissues.

Lukás Alán¹, Katarína Smolková, Eva Kronusová, Jitka Santorová, Petr Jezek.

Abstract

Existing controversies led us to analyze absolute mRNA levels of mitochondrial uncoupling proteins (UCP1-UCP5). Individual UCP isoform mRNA levels varied by up to four orders of magnitude in rat and mouse tissues. UCP2 mRNA content was relatively high (0.4 to 0.8 pg per 10 ng of total mRNA) in rat spleen, rat and mouse lung, and rat heart. Levels of the same order of magnitude were found for UCP3 mRNA in rat and mouse skeletal muscle, for UCP4 and UCP5 mRNA in mouse brain, and for UCP2 and UCP5 mRNA in mouse white adipose tissue. Significant differences in pattern were found for rat vs. mouse tissues, such as the dominance of UCP3/UCP5 vs. UCP2 transcript in mouse heart and vice versa in rat heart; or UCP2 (UCP5) dominance in rat brain contrary to 10-fold higher UCP4 and UCP5 dominance in mouse brain. We predict high antioxidant/antiapoptotic UCP function in tissues with higher UCP mRNA content.

Entities: Gene Species

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Year: 2009 PMID： 19242784 DOI： 10.1007/s10863-009-9201-2

Source DB: PubMed Journal: J Bioenerg Biomembr ISSN： 0145-479X Impact factor: 2.945

46 in total

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Journal: Biochim Biophys Acta Date: 2008-03-18

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2. Tissue-specific gene expression and functional regulation of uncoupling protein 2 (UCP2) by hypoxia and nutrient availability in gilthead sea bream (Sparus aurata): implications on the physiological significance of UCP1-3 variants.

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Review 3. Signaling pathways leading to ischemic mitochondrial neuroprotection.

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Journal: J Bioenerg Biomembr Date: 2014-09-28 Impact factor: 2.945

4. A ketone ester diet increases brain malonyl-CoA and Uncoupling proteins 4 and 5 while decreasing food intake in the normal Wistar Rat.

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Review 5. Mitochondrial dynamics in the central regulation of metabolism.

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6. Irisin protects mitochondria function during pulmonary ischemia/reperfusion injury.

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Journal: Sci Transl Med Date: 2017-11-29 Impact factor: 17.956