OBJECTIVE: To study the association between C-reactive protein levels and insulin resistance in patients with spinal cord injury. DESIGN: Cross-sectional study. SUBJECTS: Forty-two subjects who had sustained spinal cord injuries at least 6 months before enrollment. METHODS: Circulating glucose, insulin and C-reactive protein levels were measured after 12 hours' fasting. The homeo-stasis model insulin resistance index was used to evaluate insulin resistance. Insulin resistance and C-reactive protein levels were compared between complete/incomplete patients and between paraplegic/tetraplegic patients. The subjects were then divided into 3 groups (C-reactive protein levels < 1, 1-3, > 3 mg/l) to compare insulin resistance. RESULTS: Eighteen (43%) subjects had C-reactive protein levels > 3 mg/l. The C-reactive protein levels and insulin resistance did not significantly differ between complete/incomplete or between paraplegic/tetraplegic subjects. However, insulin resistance in the high C-reactive protein group (>3 mg/l) differed significantly from that of the other 2 groups, and there was a significant correlation between C-reactive protein and insulin resistance, with r=0.7745. CONCLUSION: Most young and middle-aged patients with chronic spinal cord injury with high C-reactive protein levels also have high insulin resistance, and their C-reactive protein levels have well correlated with insulin resistance.
OBJECTIVE: To study the association between C-reactive protein levels and insulin resistance in patients with spinal cord injury. DESIGN: Cross-sectional study. SUBJECTS: Forty-two subjects who had sustained spinal cord injuries at least 6 months before enrollment. METHODS: Circulating glucose, insulin and C-reactive protein levels were measured after 12 hours' fasting. The homeo-stasis model insulin resistance index was used to evaluate insulin resistance. Insulin resistance and C-reactive protein levels were compared between complete/incomplete patients and between paraplegic/tetraplegic patients. The subjects were then divided into 3 groups (C-reactive protein levels < 1, 1-3, > 3 mg/l) to compare insulin resistance. RESULTS: Eighteen (43%) subjects had C-reactive protein levels > 3 mg/l. The C-reactive protein levels and insulin resistance did not significantly differ between complete/incomplete or between paraplegic/tetraplegic subjects. However, insulin resistance in the high C-reactive protein group (>3 mg/l) differed significantly from that of the other 2 groups, and there was a significant correlation between C-reactive protein and insulin resistance, with r=0.7745. CONCLUSION: Most young and middle-aged patients with chronic spinal cord injury with high C-reactive protein levels also have high insulin resistance, and their C-reactive protein levels have well correlated with insulin resistance.
Authors: Dennis Ellenbroek; Jochen Kressler; Rachel E Cowan; Patricia A Burns; Armando J Mendez; Mark S Nash Journal: J Spinal Cord Med Date: 2014-03-12 Impact factor: 1.985
Authors: James S Krause; Nicole D DiPiro; Lee L Saunders; Susan D Newman; Narendra L Banik; Sookyoung Park Journal: Top Spinal Cord Inj Rehabil Date: 2014
Authors: Andrew D Sauerbeck; J Lukas Laws; Veera V R Bandaru; Phillip G Popovich; Norman J Haughey; Dana M McTigue Journal: J Neurotrauma Date: 2014-10-21 Impact factor: 5.269