OBJECTIVE: To determine the oxidative stress markers in serum from patients with relapsing-remitting multiple sclerosis. METHODS: Blood samples from healthy controls and 22 patients 15 women (7 aged from 20 to 30 and 8 were > 40 years old) and 7 men (5 aged from 20 to 30 and 2 were > 40 years old) fulfilling the McDonald Criteria and classified as having Relapsing-Remitting Multiple Sclerosis accordingly with Lublin were collected for oxidative stress markers quantification. RESULTS: Nitric oxide metabolites (nitrates/nitrites), lipid peroxidation products (malondialdehyde plus 4-hidroxialkenals), and glutathione peroxidase activity were significantly increased in serum of subjects with relapsing-remitting multiple sclerosis in comparison with that of healthy controls. These data support the hypothesis that multiple sclerosis is a component closely linked to oxidative stress.
OBJECTIVE: To determine the oxidative stress markers in serum from patients with relapsing-remitting multiple sclerosis. METHODS: Blood samples from healthy controls and 22 patients 15 women (7 aged from 20 to 30 and 8 were > 40 years old) and 7 men (5 aged from 20 to 30 and 2 were > 40 years old) fulfilling the McDonald Criteria and classified as having Relapsing-Remitting Multiple Sclerosis accordingly with Lublin were collected for oxidative stress markers quantification. RESULTS:Nitric oxide metabolites (nitrates/nitrites), lipid peroxidation products (malondialdehyde plus 4-hidroxialkenals), and glutathione peroxidase activity were significantly increased in serum of subjects with relapsing-remitting multiple sclerosis in comparison with that of healthy controls. These data support the hypothesis that multiple sclerosis is a component closely linked to oxidative stress.
Authors: Anette S Fjeldstad; John McDaniel; Melissa A H Witman; Steve J Ives; Jia Zhao; John W Rose; James Hannon; D Walter Wray; Russell S Richardson Journal: J Neurol Date: 2011-05-05 Impact factor: 4.849
Authors: Begoña M Escribano; Francisco J Medina-Fernández; Macarena Aguilar-Luque; Eduardo Agüera; Montserrat Feijoo; Fe I Garcia-Maceira; Rafael Lillo; Patricia Vieyra-Reyes; Ana I Giraldo; Evelio Luque; René Drucker-Colín; Isaac Túnez Journal: Neurotherapeutics Date: 2017-01 Impact factor: 7.620
Authors: Genaro G Ortiz; Fermín P Pacheco-Moisés; Oscar K Bitzer-Quintero; Ana C Ramírez-Anguiano; Luis J Flores-Alvarado; Viridiana Ramírez-Ramírez; Miguel A Macias-Islas; Erandis D Torres-Sánchez Journal: Clin Dev Immunol Date: 2013-09-24
Authors: V Ramirez-Ramirez; M A Macias-Islas; G G Ortiz; F Pacheco-Moises; E D Torres-Sanchez; T E Sorto-Gomez; J A Cruz-Ramos; G Orozco-Aviña; A J Celis de la Rosa Journal: Oxid Med Cell Longev Date: 2013-06-18 Impact factor: 6.543