Literature DB >> 1924149

Rectal mucosa damage in rabbits after subchronical application of suppository bases.

C De Muynck1, C Cuvelier, D Van Steenkiste, L Bonnarens, J P Remon.   

Abstract

The effect of suppository bases on rabbit rectal mucosa was investigated using six triglyceride bases, polyethylene glycol, and a triglyceride base combined with monoglycerides or fatty acids and methyl esters of those acids. Rectal irritation was evaluated and scored according to defined pathological features. "Pure" triglycerides and a triglyceride to which a nonionic surfactant was added caused severe mucosal damage with ulceration and inflammation. Hyperemia was characteristic for irritation by polyethylene glycol suppositories. Mucosal damage by a pure triglyceride combined with monoglycerides or fatty acids and methyl esters of those acids was similar but statistically less pronounced than with all other bases.

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Year:  1991        PMID： 1924149     DOI： 10.1023/a:1015828201697

Source DB:  PubMed          Journal:  Pharm Res        ISSN： 0724-8741            Impact factor:   4.200


  13 in total

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Authors:  F NEUWALD; J MEYER-LOHMANN
Journal:  Arzneimittelforschung       Date:  1958-09

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Authors:  E J Van Hoogdalem; J A Geerts; A G De Boer; D D Breimer
Journal:  J Pharm Pharmacol       Date:  1988-11       Impact factor: 3.765

3.  Anorectal ergotism: another cause of solitary rectal ulcers.

Authors:  V F Eckardt; G Kanzler; W Remmele
Journal:  Gastroenterology       Date:  1986-11       Impact factor: 22.682

4.  [Solitary lesions of the rectum caused by suppositories combining acetylsalicylic acid and paracetamol].

Authors:  P Lanthier; R Detry; J C Debongnie; P Mahieu; R Vanheuverzwyn
Journal:  Gastroenterol Clin Biol       Date:  1987-03

5.  Letter: Rectal bleeding and indomethacin suppositories.

Authors:  N Levy; E Gaspar
Journal:  Lancet       Date:  1975-03-08       Impact factor: 79.321

6.  Rectal delivery of antiinflammatory drugs. IV. Effect of amino acids on the change in the rectal mucosa induced by diclofenac sodium.

Authors:  H Yaginuma; Y Kohno; S Itoh; K Kubo; M Yamazaki; A Kamada; H Shimazu; T Matsuo
Journal:  Chem Pharm Bull (Tokyo)       Date:  1982-09       Impact factor: 1.645

7.  Ergotamine-induced colitis.

Authors:  B Wörmann; W Höchter; H J Seib; R Ottenjann
Journal:  Endoscopy       Date:  1985-07       Impact factor: 10.093

8.  Improvement of bioavailability of poorly absorbed drugs. V. Effect of surfactants on the promoting effect of medium chain glyceride for the rectal absorption of beta-lactam antibiotics in rats and dogs.

Authors:  M Sekine; K Sasahara; K Hasegawa; R Okada; S Awazu
Journal:  J Pharmacobiodyn       Date:  1985-08

9.  Improvement of bioavailability of poorly absorbed drugs. III. Oral acute toxicity and local irritation of medium chain glyceride.

Authors:  M Sekine; E Maeda; K Sasahara; R Okada; K Kimura; M Fukami; S Awazu
Journal:  J Pharmacobiodyn       Date:  1985-08

10.  Comparison of the effects of sodium salicylate, disodium ethylenediaminetetraacetic acid and polyoxyethylene-23-lauryl ether as adjuvants for the rectal absorption of sodium cefoxitin.

Authors:  T Nishihata; H Tomida; G Frederick; J H Rytting; T Higuchi
Journal:  J Pharm Pharmacol       Date:  1985-03       Impact factor: 3.765
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  2 in total

1.  In vivo and in vitro diclofenac sodium evaluation after rectal application of soft gelatine capsules enabling application induced transformation (AIT) into a semisolid system of liquid crystals (SSLC) for controlled release.

Authors:  A Schneeweis; C C Müller-Goymann
Journal:  Pharm Res       Date:  1997-12       Impact factor: 4.200

2.  Mechanism of absorption enhancement in humans after rectal administration of ampicillin in suppositories containing sodium caprate.

Authors:  T Lindmark; J D Söderholm; G Olaison; G Alván; G Ocklind; P Artursson
Journal:  Pharm Res       Date:  1997-07       Impact factor: 4.200
  2 in total

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