OBJECTIVES: To determine the efficacy of craniofacial resection and proton radiation for the management of esthesioneuroblastoma (ENB). DESIGN: A retrospective chart review was performed of all patients presenting with ENB and completely managed at the Massachusetts General Hospital (MGH) and the Massachusetts Eye and Ear Infirmary (MEEI) from 1997 to 2006. SETTING: A tertiary referral center. MAIN OUTCOME MEASURES: Disease-free and overall survival. PARTICIPANTS: All patients presenting with ENB and completely managed at the MGH and the MEEI from 1997 to 2006. RESULTS: Ten patients were identified with a median follow-up time of 52.8 months. Average age at presentation was 45 years. Nasal obstruction was the most common presenting symptom. Three patients presented with Kadish stage B disease and seven with stage C. No patient had evidence of cervical or metastatic disease at presentation. Seven patients were treated with craniofacial resections (CFR) followed by proton beam radiation with or without chemotherapy. Three patients were treated with initial chemotherapy with no response. They subsequently underwent CFR followed by proton beam radiation. The 5-year disease-free and overall survival rates were 90% and 85.7%, respectively, by Kaplan-Meier analysis. No patient suffered any severe radiation toxicity. CONCLUSION: ENB can be safely and effectively treated with CFR followed by proton beam irradiation. Proton irradiation may be associated with less toxicity than photon irradiation. The role of chemotherapy remains unclear.
OBJECTIVES: To determine the efficacy of craniofacial resection and proton radiation for the management of esthesioneuroblastoma (ENB). DESIGN: A retrospective chart review was performed of all patients presenting with ENB and completely managed at the Massachusetts General Hospital (MGH) and the Massachusetts Eye and Ear Infirmary (MEEI) from 1997 to 2006. SETTING: A tertiary referral center. MAIN OUTCOME MEASURES: Disease-free and overall survival. PARTICIPANTS: All patients presenting with ENB and completely managed at the MGH and the MEEI from 1997 to 2006. RESULTS: Ten patients were identified with a median follow-up time of 52.8 months. Average age at presentation was 45 years. Nasal obstruction was the most common presenting symptom. Three patients presented with Kadish stage B disease and seven with stage C. No patient had evidence of cervical or metastatic disease at presentation. Seven patients were treated with craniofacial resections (CFR) followed by proton beam radiation with or without chemotherapy. Three patients were treated with initial chemotherapy with no response. They subsequently underwent CFR followed by proton beam radiation. The 5-year disease-free and overall survival rates were 90% and 85.7%, respectively, by Kaplan-Meier analysis. No patient suffered any severe radiation toxicity. CONCLUSION: ENB can be safely and effectively treated with CFR followed by proton beam irradiation. Proton irradiation may be associated with less toxicity than photon irradiation. The role of chemotherapy remains unclear.
Authors: Herman Suit; Saveli Goldberg; Andrzej Niemierko; Alexei Trofimov; Judith Adams; Harald Paganetti; George T Y Chen; Thomas Bortfeld; Stanley Rosenthal; Jay Loeffler; Thomas Delaney Journal: Acta Oncol Date: 2003 Impact factor: 4.089
Authors: P A Levine; R L Scher; J A Jane; J A Persing; S A Newman; J Miller; R W Cantrell Journal: Otolaryngol Head Neck Surg Date: 1989-12 Impact factor: 3.497
Authors: Jannis Constantinidis; Helmut Steinhart; Michael Koch; Michael Buchfelder; Anne Schaenzer; Manfred Weidenbecher; Heinrich Iro Journal: Otolaryngol Head Neck Surg Date: 2004-05 Impact factor: 3.497
Authors: Fernando L Dias; Geraldo M Sa; Roberto A Lima; Jacob Kligerman; Marlos P Leoncio; Emilson Q Freitas; Jose Roberto N Soares; Roberto Alfonso Arcuri Journal: Arch Otolaryngol Head Neck Surg Date: 2003-11
Authors: Guillaume De Bonnecaze; B Lepage; J Rimmer; A Al Hawat; B Vairel; E Serrano; B Chaput; S Vergez Journal: Eur Arch Otorhinolaryngol Date: 2014-10-17 Impact factor: 2.503
Authors: Marc W Herr; Stacey T Gray; Audrey B Erman; William T Curry; Daniel G Deschler; Derrick T Lin Journal: J Neurol Surg B Skull Base Date: 2013-03-13
Authors: Leif Bäck; Minna Oinas; Petra Pietarinen-Runtti; Kauko Saarilahti; Jyrki Vuola; Riste Saat; Juha Öhman; Caj Haglund; Mika Niemelä; Ilmo Leivo; Jaana Hagström; Antti A Mäkitie Journal: Eur Arch Otorhinolaryngol Date: 2011-03-15 Impact factor: 2.503
Authors: Don F DeJongh; Ethan A DeJongh; Victor Rykalin; Greg DeFillippo; Mark Pankuch; Andrew W Best; George Coutrakon; Kirk L Duffin; Nicholas T Karonis; Caesar E Ordoñez; Christina Sarosiek; Reinhard W Schulte; John R Winans; Alec M Block; Courtney L Hentz; James S Welsh Journal: Med Phys Date: 2021-11-18 Impact factor: 4.071
Authors: Matthew R Naunheim; Neerav Goyal; Matthew M Dedmon; Kyle J Chambers; Ahmad R Sedaghat; Benjamin S Bleier; Eric H Holbrook; William T Curry; Stacey T Gray; Derrick T Lin Journal: J Neurol Surg B Skull Base Date: 2016-03-18
Authors: Marc W Herr; Rosh K V Sethi; Joshua C Meier; Kyle J Chambers; Aaron Remenschneider; Annie Chan; William T Curry; Fred G Barker; Daniel G Deschler; Derrick T Lin Journal: J Neurol Surg B Skull Base Date: 2013-09-20
Authors: Sana D Karam; Ann K Jay; Cynthia Anyanwu; Matthew K Steehler; Bruce Davidson; Pedro Debrito; K William Harter Journal: Front Oncol Date: 2014-03-14 Impact factor: 6.244