| Literature DB >> 1923936 |
W F Herblin1, S M Diamond, P B Timmermans.
Abstract
The localization of subtypes of the angiotensin II receptor has been determined by autoradiographic techniques using iodinated angiotensin II and two nonpeptide antagonists that exhibit selective affinities. DuP 753 specifically displaces type 1 sites (AII-1) and PD123177 inhibits only type 2 sites (AII-2). The rabbit adrenal cortex contains predominately AII-1 sites and the few AII-2 sites that are present are nonuniformly distributed. In the rabbit kidney, the fibrous outer sheath contains exclusively AII-2 sites whereas the glomeruli of the renal cortex and the renal medulla exhibit only AII-1 sites.Entities:
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Year: 1991 PMID： 1923936 DOI： 10.1016/0196-9781(91)90105-x
Source DB: PubMed Journal: Peptides ISSN： 0196-9781 Impact factor: 3.750