| Literature DB >> 19239144 |
Sanya Roysommuti1, Atchariya Suwanich, Wichaporn Lerdweeraphon, Atcharaporn Thaeomor, Dusit Jirakulsomchok, J Michael Wyss.
Abstract
The present study tests the sex-dependent effect of perinatal taurine exposure on arterial pressure control in adults. Female Sprague-Dawley rats were fed normal rat chow with 3% beta-alanine (taurine depletion,TD), 3% taurine (taurine supplementation,TS) or water alone (C) from conception to weaning. Their male and female offspring were then fed normal rat chow and tap water with 5% glucose (C with glucose, CG; TD with glucose, TDG; TS with glucose, TSG) or water alone (CW, TDW or TSW). At 7-8 weeks of age, they were studied in a conscious condition. Body weights were lower in male and female TDG and male TDW rats. Kidney to body weights increased in female TSW but not TSG. Plasma sodium and potassium were not significantly different among males. Among females, plasma sodium levels were lower in all glucose treated groups while plasma potassium levels were lower only in TDG. Hematocrit, fasting blood glucose, and glucose tolerance were not significantly different between the sexes. Mean arterial pressure increased in male TDG, TSW, and TSG while in the females, mean arterial pressure increased in TabstractDW, TDG, and TSG. Heart rates were not significantly different between the sexes. The present data indicate that perinatal taurine exposure alters arterial pressure control of adult rats and this effect is gender specific.Entities:
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Year: 2009 PMID： 19239144 PMCID： PMC2672946 DOI： 10.1007/978-0-387-75681-3_14
Source DB: PubMed Journal: Adv Exp Med Biol ISSN： 0065-2598 Impact factor: 2.622