Literature DB >> 19238729

Sox17 facilitates the differentiation of mouse embryonic stem cells into primitive and definitive endoderm in vitro.

Xue-Bin Qu1, Jie Pan, Cong Zhang, Shu-Yang Huang.   

Abstract

The Sox family of HMG (high mobility group)-box transcription factors are highly conserved in vertebrates. Sox members are involved in various developmental processes. Among them Sox17 has been demonstrated to function as an endoderm determinant in zebrafish and Xenopus, respectively. However, little is known about the role of Sox17 in mouse embryonic stem cell (ESC) differentiation. In our research, we investigated the effect of Sox17 on mouse ESC and embryoid body (EB) differentiation. The results demonstrated that Sox17 overexpression upregulated a set of endoderm-specific gene markers, suggesting that Sox17 overexpression induced an ESC differentiation program towards both primitive and definitive endoderm. We believe this finding brings new insights into the understanding of ESC differentiation and the organogenesis of endodermal derivatives.

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Year:  2008        PMID： 19238729     DOI： 10.1111/j.1440-169x.2008.01056.x

Source DB:  PubMed          Journal:  Dev Growth Differ        ISSN： 0012-1592            Impact factor:   2.053


  15 in total

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Journal:  Thyroid       Date:  2015-03-23       Impact factor: 6.568

3.  Spatio-temporal re-organization of replication foci accompanies replication domain consolidation during human pluripotent stem cell lineage specification.

Authors:  Korey A Wilson; Andrew G Elefanty; Edouard G Stanley; David M Gilbert
Journal:  Cell Cycle       Date:  2016-07-19       Impact factor: 4.534

4.  Proteomic analysis of Sox2-associated proteins during early stages of mouse embryonic stem cell differentiation identifies Sox21 as a novel regulator of stem cell fate.

Authors:  Sunil K Mallanna; Briana D Ormsbee; Michelina Iacovino; Joshua M Gilmore; Jesse L Cox; Michael Kyba; Michael P Washburn; Angie Rizzino
Journal:  Stem Cells       Date:  2010-10       Impact factor: 6.277

5.  The primitive endoderm lineage of the mouse blastocyst: sequential transcription factor activation and regulation of differentiation by Sox17.

Authors:  Jérôme Artus; Anna Piliszek; Anna-Katerina Hadjantonakis
Journal:  Dev Biol       Date:  2010-12-10       Impact factor: 3.582

6.  Derivation of extraembryonic endoderm stem (XEN) cells from mouse embryos and embryonic stem cells.

Authors:  Kathy K Niakan; Nadine Schrode; Lily T Y Cho; Anna-Katerina Hadjantonakis
Journal:  Nat Protoc       Date:  2013-05-02       Impact factor: 13.491

7.  Origin and formation of the first two distinct cell types of the inner cell mass in the mouse embryo.

Authors:  Samantha A Morris; Roy T Y Teo; Huiliang Li; Paul Robson; David M Glover; Magdalena Zernicka-Goetz
Journal:  Proc Natl Acad Sci U S A       Date:  2010-03-22       Impact factor: 11.205

8.  Cell-surface proteomics identifies lineage-specific markers of embryo-derived stem cells.

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Journal:  Dev Cell       Date:  2012-03-15       Impact factor: 12.270

9.  Efficient and directive generation of two distinct endoderm lineages from human ESCs and iPSCs by differentiation stage-specific SOX17 transduction.

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Journal:  PLoS One       Date:  2011-07-07       Impact factor: 3.240

10.  STELLA facilitates differentiation of germ cell and endodermal lineages of human embryonic stem cells.

Authors:  Patompon Wongtrakoongate; Mark Jones; Paul J Gokhale; Peter W Andrews
Journal:  PLoS One       Date:  2013-02-14       Impact factor: 3.240
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