Literature DB >> 19237652

Antibacterial activity of ultrashort cationic lipo-beta-peptides.

Griselda N Serrano1, George G Zhanel, Frank Schweizer.   

Abstract

Previously reported D,L-lipo-alpha-peptides and their lipo-beta-peptide counterparts (C16-KGGK, C16-KAAK, C16-KKKK, and C12-KLLK) were studied, and the lipo-beta-peptides were found to retain antimicrobial activity. Likewise, no significant changes in antimicrobial activity were found upon activity comparisons with D,L-amino acid-based lipopeptides or any L-amino acid lipopeptides. As a defined amphipathic structure is unlikely to form with such short molecules and as similar activities were obtained from all lipopeptides, we suspect that the action of membrane permeation is retained.

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Year:  2009        PMID: 19237652      PMCID: PMC2681537          DOI: 10.1128/AAC.01100-08

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN: 0066-4804            Impact factor:   5.191


  13 in total

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4.  The acyl group as the central element of the structural organization of antimicrobial lipopeptide.

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Journal:  J Am Chem Soc       Date:  2007-02-07       Impact factor: 15.419

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Journal:  Antimicrob Agents Chemother       Date:  2008-02-19       Impact factor: 5.191

10.  Bestowing antifungal and antibacterial activities by lipophilic acid conjugation to D,L-amino acid-containing antimicrobial peptides: a plausible mode of action.

Authors:  Dorit Avrahami; Yechiel Shai
Journal:  Biochemistry       Date:  2003-12-23       Impact factor: 3.162

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  15 in total

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Authors:  Christopher D Fjell; Jan A Hiss; Robert E W Hancock; Gisbert Schneider
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Review 2.  Cationic amphiphiles, a new generation of antimicrobials inspired by the natural antimicrobial peptide scaffold.

Authors:  Brandon Findlay; George G Zhanel; Frank Schweizer
Journal:  Antimicrob Agents Chemother       Date:  2010-08-09       Impact factor: 5.191

3.  Thermodynamics of Micelle Formation and Membrane Fusion Modulate Antimicrobial Lipopeptide Activity.

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Journal:  Biophys J       Date:  2015-08-18       Impact factor: 4.033

4.  Boosting salt resistance of short antimicrobial peptides.

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5.  Thermodynamics of antimicrobial lipopeptide binding to membranes: origins of affinity and selectivity.

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Journal:  Biophys J       Date:  2014-10-21       Impact factor: 4.033

Review 6.  Advances in Development of Antimicrobial Peptidomimetics as Potential Drugs.

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Journal:  Molecules       Date:  2017-08-29       Impact factor: 4.411

7.  Limiting an antimicrobial peptide to the lipid-water interface enhances its bacterial membrane selectivity: a case study of MSI-367.

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8.  Antimicrobial Activity of Novel Synthetic Peptides Derived from Indolicidin and Ranalexin against Streptococcus pneumoniae.

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9.  Novel antimicrobial peptides with high anticancer activity and selectivity.

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10.  Antimicrobial and Antibiofilm Activity of UP-5, an Ultrashort Antimicrobial Peptide Designed Using Only Arginine and Biphenylalanine.

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Journal:  Pharmaceuticals (Basel)       Date:  2018-01-02
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