BACKGROUND: A significant relationship has been noted between the lipid profile and atherosclerotic coronary artery disease (CAD) using invasive coronary angiography. We tested the hypothesis that the severity of CAD as determined by a non-invasive method, multi-detector row computed tomography (MDCT), is also associated with lipidemic factors. METHODS AND RESULTS: The subjects included 195 consecutive patients who underwent coronary angiography using MDCT because of suspected CAD. The number of significantly stenosed vessels (VD) as evaluated by MDCT, platelet-activating factor acetylhydrolase (PAF-AH), free cholesterol (FC), phospholipid (PL), remnant-like lipoprotein particle-cholesterol (RLP-C), apolipoprotein (apo)-B, apo-C3, apo-E, and highly-sensitive C-reactive protein were determined. The subjects were divided into diabetes mellitus (DM) and non-DM groups. The HDL-associated PAF-AH level in the DM group was significantly lower than that in the non-DM group. The VD determined by MDCT was significantly associated with hypertension, administration of angiotensin II type 1 receptor blocker, high-density lipoprotein cholesterol (HDL-C), HDL-associated (H)-HDL, H-PL, H-FC and RLP-C. Multivariate analysis revealed that VD determined by MDCT was most closely correlated with HDL-C. CONCLUSION: Lower levels of HDL-C may be an indicator for and provide additional information regarding the severity of CAD compared with other lipidemic factors. Copyright (c) 2009 Elsevier Ireland Ltd. All rights reserved.
BACKGROUND: A significant relationship has been noted between the lipid profile and atherosclerotic coronary artery disease (CAD) using invasive coronary angiography. We tested the hypothesis that the severity of CAD as determined by a non-invasive method, multi-detector row computed tomography (MDCT), is also associated with lipidemic factors. METHODS AND RESULTS: The subjects included 195 consecutive patients who underwent coronary angiography using MDCT because of suspected CAD. The number of significantly stenosed vessels (VD) as evaluated by MDCT, platelet-activating factor acetylhydrolase (PAF-AH), free cholesterol (FC), phospholipid (PL), remnant-like lipoprotein particle-cholesterol (RLP-C), apolipoprotein (apo)-B, apo-C3, apo-E, and highly-sensitive C-reactive protein were determined. The subjects were divided into diabetes mellitus (DM) and non-DM groups. The HDL-associated PAF-AH level in the DM group was significantly lower than that in the non-DM group. The VD determined by MDCT was significantly associated with hypertension, administration of angiotensin II type 1 receptor blocker, high-density lipoprotein cholesterol (HDL-C), HDL-associated (H)-HDL, H-PL, H-FC and RLP-C. Multivariate analysis revealed that VD determined by MDCT was most closely correlated with HDL-C. CONCLUSION: Lower levels of HDL-C may be an indicator for and provide additional information regarding the severity of CAD compared with other lipidemic factors. Copyright (c) 2009 Elsevier Ireland Ltd. All rights reserved.
Authors: Ibrahim Aboshady; Dianna D Cody; Evan M Johnson; Amir Gahremanpour; Deborah Vela; Kamal G Khalil; Herbert L Dupont; James T Willerson; L Maximilian Buja; Gregory W Gladish Journal: Int J Cardiol Date: 2010-12-24 Impact factor: 4.164
Authors: Jose Luis Sánchez-Quesada; Irene Vinagre; Elena De Juan-Franco; Juan Sánchez-Hernández; Rosa Bonet-Marques; Francisco Blanco-Vaca; Jordi Ordóñez-Llanos; Antonio Pérez Journal: Cardiovasc Diabetol Date: 2013-08-05 Impact factor: 9.951