BACKGROUND: The physiology of adipose tissue plays a main role in the pathogenesis of type 2 diabetes mellitus. The secretion of adipocyte-derived hormones, in either an autocrine or a paracrine manner, has been proposed as a relevant mechanism in this process. In this sense, the administration and regulation of hormones derived from adipose tissue arises as an attractive option for treating metabolic disorders. OBJECTIVE: To review the current understanding of the implication of adipokines in the development of obesity and insulin resistance, as well as their potential use as therapeutic agents. METHODOLOGY: Review of scientific literature. CONCLUSIONS: This review describes the role of adipokines in generating insulin resistance and the chronic low-grade inflammatory profile accompanying visceral obesity.
BACKGROUND: The physiology of adipose tissue plays a main role in the pathogenesis of type 2 diabetes mellitus. The secretion of adipocyte-derived hormones, in either an autocrine or a paracrine manner, has been proposed as a relevant mechanism in this process. In this sense, the administration and regulation of hormones derived from adipose tissue arises as an attractive option for treating metabolic disorders. OBJECTIVE: To review the current understanding of the implication of adipokines in the development of obesity and insulin resistance, as well as their potential use as therapeutic agents. METHODOLOGY: Review of scientific literature. CONCLUSIONS: This review describes the role of adipokines in generating insulin resistance and the chronic low-grade inflammatory profile accompanying visceral obesity.
Authors: M Gorety Jacobo-Cejudo; Roxana Valdés-Ramos; Ana L Guadarrama-López; Rosa-Virgen Pardo-Morales; Beatriz E Martínez-Carrillo; Laurence S Harbige Journal: Nutrients Date: 2017-06-03 Impact factor: 5.717
Authors: Sarwar Hashmi; Yi Wang; Ranjit S Parhar; Kate S Collison; Walter Conca; Futwan Al-Mohanna; Randy Gaugler Journal: Nutr Metab (Lond) Date: 2013-04-04 Impact factor: 4.169
Authors: Ana I Pérez-Hernández; Victoria Catalán; Javier Gómez-Ambrosi; Amaia Rodríguez; Gema Frühbeck Journal: Front Endocrinol (Lausanne) Date: 2014-05-01 Impact factor: 5.555