| Literature DB >> 19235591 |
Stavroula Baritaki1, Anthoula M Chatzinikola, Antonios F Vakis, Nikolaos Soulitzis, Dimitris A Karabetsos, Ioannis Neonakis, Benjamin Bonavida, Demetrios A Spandidos.
Abstract
In this study we examined by QRT-PCR the mRNA expression of TGF-beta 1, IGF-1, EGF, FGF-2 and YY1 in human brain tumors. Our findings introduce YY1, for the first time, as a novel gene implicated in brain gliomatogenesis and meningioma establishment. We present a positive correlation between the autocrine expression of YY1 and TGF-beta 1, IGF-1 and FGF-2, known to be involved in the progression of gliomas and meningiomas. We suggest that mRNA profiling of the above genes in the early stages of disease development could be useful for prognostic purposes, and these genes can be considered as potential targets for therapeutic approaches against brain tumors.Entities:
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Year: 2009 PMID： 19235591 DOI： 10.1080/07357900802210760
Source DB: PubMed Journal: Cancer Invest ISSN： 0735-7907 Impact factor: 2.176