Literature DB >> 19234875

Transcriptional profiles of response to terbinafine in Trichophyton rubrum.

Wenliang Zhang1, Lu Yu, Jian Yang, Lingling Wang, Junping Peng, Qi Jin.   

Abstract

Trichophyton rubrum is a good model for the study of human pathogenic filamentous fungi. The antifungal agent terbinafine (TRB) shows specific activity against T. rubrum. To identify the transcriptional profiles of response to TRB in T. rubrum, a cDNA microarray was constructed from the expressed sequence tags of different phase cDNA libraries and transcriptional profiles of the response to TRB were determined. Exposure to TRB decreased the transcription of some genes involved in the ergosterol biosynthesis pathway, including ERG2, ERG4, ERG24, and ERG25, and induced the expression of some genes involved in lipid metabolism such as ERG10, ERG13, and INO1. TRB affected transcription of multidrug-resistance genes and some genes encoding ribosomal proteins.

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Year:  2009        PMID： 19234875     DOI： 10.1007/s00253-009-1908-9

Source DB:  PubMed          Journal:  Appl Microbiol Biotechnol        ISSN： 0175-7598            Impact factor:   4.813


  13 in total

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Authors:  Anke Burmester; Ekaterina Shelest; Gernot Glöckner; Christoph Heddergott; Susann Schindler; Peter Staib; Andrew Heidel; Marius Felder; Andreas Petzold; Karol Szafranski; Marc Feuermann; Ivo Pedruzzi; Steffen Priebe; Marco Groth; Robert Winkler; Wenjun Li; Olaf Kniemeyer; Volker Schroeckh; Christian Hertweck; Bernhard Hube; Theodore C White; Matthias Platzer; Reinhard Guthke; Joseph Heitman; Johannes Wöstemeyer; Peter F Zipfel; Michel Monod; Axel A Brakhage
Journal:  Genome Biol       Date:  2011-01-19       Impact factor: 13.583

2.  Dermatophyte virulence factors: identifying and analyzing genes that may contribute to chronic or acute skin infections.

Authors:  Rebecca Rashid Achterman; Theodore C White
Journal:  Int J Microbiol       Date:  2011-10-04

3.  RNA-sequencing analysis of Trichophyton rubrum transcriptome in response to sublethal doses of acriflavine.

Authors:  Gabriela Felix Persinoti; Nalu Teixeira de Aguiar Peres; Tiago Rinaldi Jacob; Antonio Rossi; Ricardo Zorzetto Vêncio; Nilce Maria Martinez-Rossi
Journal:  BMC Genomics       Date:  2014-10-27       Impact factor: 3.969

4.  Molecular and cellular responses of the pathogenic fungus Lomentospora prolificans to the antifungal drug voriconazole.

Authors:  Aize Pellon; Andoni Ramirez-Garcia; Idoia Buldain; Aitziber Antoran; Aitor Rementeria; Fernando L Hernando
Journal:  PLoS One       Date:  2017-03-31       Impact factor: 3.240

5.  Gene Expression Response of Trichophyton rubrum during Coculture on Keratinocytes Exposed to Antifungal Agents.

Authors:  Tatiana Takahasi Komoto; Tamires Aparecida Bitencourt; Gabriel Silva; Rene Oliveira Beleboni; Mozart Marins; Ana Lúcia Fachin
Journal:  Evid Based Complement Alternat Med       Date:  2015-07-14       Impact factor: 2.629

6.  Trans-chalcone and quercetin down-regulate fatty acid synthase gene expression and reduce ergosterol content in the human pathogenic dermatophyte Trichophyton rubrum.

Authors:  Tamires Aparecida Bitencourt; Tatiana Takahasi Komoto; Bruna Gabriele Massaroto; Carlos Eduardo Saraiva Miranda; Rene Oliveira Beleboni; Mozart Marins; Ana Lúcia Fachin
Journal:  BMC Complement Altern Med       Date:  2013-09-17       Impact factor: 3.659

7.  Heat Shock Proteins in Dermatophytes: Current Advances and Perspectives.

Authors:  Nilce M Martinez-Rossi; Tiago R Jacob; Pablo R Sanches; Nalu T A Peres; Elza A S Lang; Maíra P Martins; Antonio Rossi
Journal:  Curr Genomics       Date:  2016-04       Impact factor: 2.236

8.  Heat Shock Protein 90 (Hsp90) as a Molecular Target for the Development of Novel Drugs Against the Dermatophyte Trichophyton rubrum.

Authors:  Tiago R Jacob; Nalu T A Peres; Maíra P Martins; Elza A S Lang; Pablo R Sanches; Antonio Rossi; Nilce M Martinez-Rossi
Journal:  Front Microbiol       Date:  2015-11-10       Impact factor: 5.640

9.  Abnormal Ergosterol Biosynthesis Activates Transcriptional Responses to Antifungal Azoles.

Authors:  Chengcheng Hu; Mi Zhou; Wenzhao Wang; Xianyun Sun; Oded Yarden; Shaojie Li
Journal:  Front Microbiol       Date:  2018-01-17       Impact factor: 5.640

Review 10.  Dermatophyte Resistance to Antifungal Drugs: Mechanisms and Prospectus.

Authors:  Nilce M Martinez-Rossi; Tamires A Bitencourt; Nalu T A Peres; Elza A S Lang; Eriston V Gomes; Natalia R Quaresemin; Maíra P Martins; Lucia Lopes; Antonio Rossi
Journal:  Front Microbiol       Date:  2018-05-29       Impact factor: 5.640
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