Literature DB >> 19234481

Effects of TRPM8 on the proliferation and motility of prostate cancer PC-3 cells.

Zhong-Hua Yang1, Xing-Huan Wang, Huai-Peng Wang, Li-Quan Hu.   

Abstract

We investigated the effects of transient receptor potential M8 (TRPM8) channel on the proliferation and motility of androgen-independent prostate cancer PC-3 cells. After being permanently transfected with an empty vector and cDNA encoding the TRPM8 protein, cells were analysed for cell cycle distribution and motility using flow cytometry and scratch assay. Immunocytochemistry and Ca2+ imaging analysis revealed the overexpression of functional TRPM8 channel on both endoplasmic reticulum and plasma membrane of PC-3-TRPM8 cells. Cell cycle distribution and scratch assay analysis revealed that TRPM8 induced cell cycle arrest at the G0/G1 stage (P < 0.05) and facilitated the cell apoptosis induced by starvation (P < 0.05). Furthermore, TRPM8 inhibited the migration of PC-3-TRPM8 cells (P < 0.01) through the inactivation of focal-adhesion kinase. It appears that TRPM8 was not essential for the survival of PC-3 cells; however, the overexpression of TRPM8 had negative effects on the proliferation and migration of PC-3 cells. Thus, TRPM8 and its agonists may serve as important targets for the treatment of prostate cancer.

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Year:  2009        PMID： 19234481      PMCID： PMC3735032          DOI： 10.1038/aja.2009.1

Source DB:  PubMed          Journal:  Asian J Androl        ISSN： 1008-682X            Impact factor:   3.285


  18 in total

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2.  Ca2+ pools and cell growth. Evidence for sarcoendoplasmic Ca2+-ATPases 2B involvement in human prostate cancer cell growth control.

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4.  Trp-p8, a novel prostate-specific gene, is up-regulated in prostate cancer and other malignancies and shares high homology with transient receptor potential calcium channel proteins.

Authors:  L Tsavaler; M H Shapero; S Morkowski; R Laus
Journal:  Cancer Res       Date:  2001-05-01       Impact factor: 12.701

5.  Store-operated Ca2+ current in prostate cancer epithelial cells. Role of endogenous Ca2+ transporter type 1.

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6.  Store depletion and store-operated Ca2+ current in human prostate cancer LNCaP cells: involvement in apoptosis.

Authors:  R Skryma; P Mariot; X L Bourhis; F V Coppenolle; Y Shuba; F Vanden Abeele; G Legrand; S Humez; B Boilly; N Prevarskaya
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  42 in total

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4.  Intracellular calcium oscillations in strongly metastatic human breast and prostate cancer cells: control by voltage-gated sodium channel activity.

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5.  Menthol inhibits the proliferation and motility of prostate cancer DU145 cells.

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Review 6.  The endocannabinoid system in prostate cancer.

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7.  TRPM8 and prostate cancer: to overexpress or repress, that is the question-comment on "Effects of TRPM8 on proliferation and motility of prostate cancer PC-3 cells" by Yang ZH et al. in Asian Journal of Andrology.

Authors:  Prakash Kulkarni
Journal:  Asian J Androl       Date:  2009-02-23       Impact factor: 3.285

8.  Identification of candidate genes that may contribute to the metastasis of prostate cancer by bioinformatics analysis.

Authors:  Lingyun Liu; Kaimin Guo; Zuowen Liang; Fubiao Li; Hongliang Wang
Journal:  Oncol Lett       Date:  2017-11-14       Impact factor: 2.967

9.  Effects of TRPM8 on the proliferation and angiogenesis of prostate cancer PC-3 cells in vivo.

Authors:  Guangbin Zhu; Xinghuan Wang; Zhonghua Yang; Hong Cao; Zhe Meng; Yongzhi Wang; Dong Chen
Journal:  Oncol Lett       Date:  2011-09-02       Impact factor: 2.967

10.  Expression of TRPC6 in benign and malignant human prostate tissues.

Authors:  Dan Yue; Yong Wang; Jian-Ying Xiao; Ping Wang; Chang-Shan Ren
Journal:  Asian J Androl       Date:  2009-08-24       Impact factor: 3.285
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