| Literature DB >> 19233649 |
Maosheng Duan1, Christopher Aquino, Robert Ferris, Wieslaw M Kazmierski, Terry Kenakin, Cecilia Koble, Pat Wheelan, Chris Watson, Michael Youngman.
Abstract
Several series of CCR5 antagonists have been discovered by derivatization at the N-terminal of the piperidine ring of the core template 2. Some derivatives exhibited potent inhibition against HIV-1infection. The pharmacokinetic properties of the lead compounds 11a, 14a, 15b, and 16b have been evaluated in vivo.Entities:
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Year: 2009 PMID： 19233649 DOI： 10.1016/j.bmcl.2009.02.014
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823