Literature DB >> 19233645

New prostaglandin derivative for glaucoma treatment.

Elena Perrino1, Caterina Uliva, Cecilia Lanzi, Piero Del Soldato, Emanuela Masini, Anna Sparatore.   

Abstract

A hydrogen sulphide-releasing derivative of latanoprost acid (ACS 67) was synthesized and tested in vivo to evaluate its activity on reduction of intraocular pressure and tolerability. Glutathione (GSH) and cGMP content were also measured in the aqueous humour. The increased reduction of intraocular pressure, with a marked increase of GSH and cGMP and the related potential neuroprotective properties, make this compound interesting for the treatment of glaucoma. This is the first time that an application of a hydrogen sulphide-releasing molecule is reported for the treatment of ocular diseases.

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Year:  2009        PMID： 19233645     DOI： 10.1016/j.bmcl.2009.02.007

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  16 in total

1.  In vitro-controlled release delivery system for hydrogen sulfide donor.

Authors:  Hatim Ali; Catherine Opere; Somnath Singh
Journal:  AAPS PharmSciTech       Date:  2014-04-24       Impact factor: 3.246

2.  Inhibitory action of novel hydrogen sulfide donors on bovine isolated posterior ciliary arteries.

Authors:  Madhura Kulkarni-Chitnis; Ya Fatou Njie-Mbye; Leah Mitchell; Jenaye Robinson; Matthew Whiteman; Mark E Wood; Catherine A Opere; Sunny E Ohia
Journal:  Exp Eye Res       Date:  2015-04-04       Impact factor: 3.467

3.  Effects of Hydrogen Sulfide-Releasing Compounds on Aqueous Humor Outflow Facility in Porcine Ocular Anterior Segments, Ex Vivo.

Authors:  Jenaye Robinson; Esther Okoro; Chinoso Ezuedu; Leah Bush; Catherine A Opere; Sunny E Ohia; Ya Fatou Njie-Mbye
Journal:  J Ocul Pharmacol Ther       Date:  2017-01-18       Impact factor: 2.671

4.  Hydrogen sulfide-induced inhibition of L-type Ca2+ channels and insulin secretion in mouse pancreatic beta cells.

Authors:  G Tang; L Zhang; G Yang; L Wu; R Wang
Journal:  Diabetologia       Date:  2012-12-30       Impact factor: 10.122

Review 5.  Regulation of Aqueous Humor Dynamics by Hydrogen Sulfide: Potential Role in Glaucoma Pharmacotherapy.

Authors:  Sunny E Ohia; Jenaye Robinson; Leah Mitchell; Kalu K Ngele; Segewkal Heruye; Catherine A Opere; Ya Fatou Njie-Mbye
Journal:  J Ocul Pharmacol Ther       Date:  2017-12-07       Impact factor: 2.671

Review 6.  The dichotomous role of H2S in cancer cell biology? Déjà vu all over again.

Authors:  Khosrow Kashfi
Journal:  Biochem Pharmacol       Date:  2018-02-14       Impact factor: 5.858

7.  Slow regulated release of H2S inhibits oxidative stress induced cell death by influencing certain key signaling molecules.

Authors:  Aman Shah Abdul Majid; Amin Malik Shah Abdul Majid; Zheng Qin Yin; Dan Ji
Journal:  Neurochem Res       Date:  2013-04-14       Impact factor: 3.996

Review 8.  Anti-cancer activity of new designer hydrogen sulfide-donating hybrids.

Authors:  Khosrow Kashfi
Journal:  Antioxid Redox Signal       Date:  2013-06-07       Impact factor: 8.401

9.  Effect of Hydrogen Sulfide Donors on Intraocular Pressure in Rabbits.

Authors:  Ankita Salvi; Pratik Bankhele; Jamal Jamil; Madhura Kulkarni Chitnis; Ya Fatou Njie-Mbye; Sunny E Ohia; Catherine A Opere
Journal:  J Ocul Pharmacol Ther       Date:  2016-04-19       Impact factor: 2.671

10.  Pharmacological Actions of Hydrogen Sulfide Donors on Sympathetic Neurotransmission in the Bovine Anterior Uvea, In Vitro.

Authors:  Ankita Salvi; Pratik Bankhele; Jamal M Jamil; Madhura Kulkarni-Chitnis; Ya Fatou Njie-Mbye; Sunny E Ohia; Catherine A Opere
Journal:  Neurochem Res       Date:  2015-12-23       Impact factor: 3.996
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