| Literature DB >> 19233642 |
Jie Liu1, Hao Ren, Jinyi Xu, Renren Bai, Qi Yan, Wenlong Huang, Xiaoming Wu, Jihua Fu, Qiujuan Wang, Qian Wu, Rong Fu.
Abstract
This letter describes the total synthesis, preliminary biological evaluation and mechanism studies of a novel and structurally unique isochromanone, (+/-)7,8-dihydroxy-3-methyl-isochromanone-4 (1), a nature product contained in banana (Musa sapientum L.) peel. The bioassay showed that compound 1 displays potent antihypertensive activity in renal hypertensive rats and further mechanism studies revealed that it is an ACE inhibitor.Entities:
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Year: 2008 PMID： 19233642 DOI： 10.1016/j.bmcl.2008.12.102
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823