Literature DB >> 19233348

Probing replacement of pyrophosphate via click chemistry; synthesis of UDP-sugar analogues as potential glycosyl transferase inhibitors.

Kar Kheng Yeoh1, Terry D Butters, Brendan L Wilkinson, Antony J Fairbanks.   

Abstract

A series of potential UDP-sugar mimics were readily synthesised by copper(I) catalysed modified Huisgen cycloaddition of the corresponding alpha-propargyl glycosides with 5-azido uridine in aqueous solution. None of the compounds accessed displayed significant inhibitory activity at concentrations of up to 4.5mM in an assay against bovine milk beta-1,4-galactosyltransferase.

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Year:  2009        PMID： 19233348     DOI： 10.1016/j.carres.2009.01.001

Source DB:  PubMed          Journal:  Carbohydr Res        ISSN： 0008-6215            Impact factor:   2.104


  5 in total

1.  Simple and efficient synthesis of 5'-aryl-5'-deoxyguanosine analogs by azide-alkyne click reaction and their antileishmanial activities.

Authors:  Pierre Daligaux; Sébastien Pomel; Karine Leblanc; Philippe M Loiseau; Christian Cavé
Journal:  Mol Divers       Date:  2016-01-11       Impact factor: 2.943

2.  Ultrasonic assisted Fischer glycosylation: generating diversity for glycochemistry.

Authors:  Nasrin Shaikh; Laura Russo; Laura Cipolla; Francesco Nicotra
Journal:  Mol Divers       Date:  2010-10-08       Impact factor: 2.943

3.  Nucleoside triphosphate mimicry: a sugar triazolyl nucleoside as an ATP-competitive inhibitor of B. anthracis pantothenate kinase.

Authors:  Andrew S Rowan; Nathan I Nicely; Nicola Cochrane; Wjatschesslaw A Wlassoff; Al Claiborne; Chris J Hamilton
Journal:  Org Biomol Chem       Date:  2009-07-27       Impact factor: 3.876

4.  'Click cyclic ADP-ribose': a neutral second messenger mimic.

Authors:  Joanna M Swarbrick; Richard Graeff; Clive Garnham; Mark P Thomas; Antony Galione; Barry V L Potter
Journal:  Chem Commun (Camb)       Date:  2014-01-23       Impact factor: 6.222

5.  Design, Synthesis and Molecular Modeling Study of Conjugates of ADP and Morpholino Nucleosides as A Novel Class of Inhibitors of PARP-1, PARP-2 and PARP-3.

Authors:  Yuliya V Sherstyuk; Nikita V Ivanisenko; Alexandra L Zakharenko; Maria V Sukhanova; Roman Y Peshkov; Ilia V Eltsov; Mikhail M Kutuzov; Tatjana A Kurgina; Ekaterina A Belousova; Vladimir A Ivanisenko; Olga I Lavrik; Vladimir N Silnikov; Tatyana V Abramova
Journal:  Int J Mol Sci       Date:  2019-12-27       Impact factor: 5.923
  5 in total

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