Literature DB >> 19233223

Isolation of azaspiracid-2 from a marine sponge Echinoclathria sp. as a potent cytotoxin.

Reiko Ueoka1, Akihiro Ito, Miho Izumikawa, Satoko Maeda, Motoki Takagi, Kazuo Shin-ya, Minoru Yoshida, Rob W M van Soest, Shigeki Matsunaga.   

Abstract

Azaspiracid-2 was isolated from a marine sponge Echinoclathria sp. collected off Amami-Oshima as the predominant cytotoxic constituent. A combination of HPLC using ODS, GS320, and Phenylhexyl stationary phases permitted the purification without using acid or inorganic additives in the mobile phase. Azaspiracid-2 exhibited potent cytotoxicity against P388 cells with an IC50 value of 0.72 ng/mL and caused S phase arrest on the cell cycle.

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Year:  2009        PMID： 19233223     DOI： 10.1016/j.toxicon.2009.02.008

Source DB:  PubMed          Journal:  Toxicon        ISSN： 0041-0101            Impact factor:   3.033


  7 in total

1.  Microsphere-based immunoassay for the detection of azaspiracids.

Authors:  Laura P Rodríguez; Natalia Vilariño; M Carmen Louzao; Tobin J Dickerson; K C Nicolaou; Michael O Frederick; Luis M Botana
Journal:  Anal Biochem       Date:  2013-11-08       Impact factor: 3.365

2.  Production and isolation of azaspiracid-1 and -2 from Azadinium spinosum culture in pilot scale photobioreactors.

Authors:  Thierry Jauffrais; Jane Kilcoyne; Véronique Séchet; Christine Herrenknecht; Philippe Truquet; Fabienne Hervé; Jean Baptiste Bérard; Cíara Nulty; Sarah Taylor; Urban Tillmann; Christopher O Miles; Philipp Hess
Journal:  Mar Drugs       Date:  2012-06-13       Impact factor: 6.085

Review 3.  Human Poisoning from Marine Toxins: Unknowns for Optimal Consumer Protection.

Authors:  Natalia Vilariño; M Carmen Louzao; Paula Abal; Eva Cagide; Cristina Carrera; Mercedes R Vieytes; Luis M Botana
Journal:  Toxins (Basel)       Date:  2018-08-09       Impact factor: 4.546

4.  Effects of Temperature, Growth Media, and Photoperiod on Growth and Toxin Production of Azadinium spinosum.

Authors:  Jane Kilcoyne; Amy McCoy; Stephen Burrell; Bernd Krock; Urban Tillmann
Journal:  Mar Drugs       Date:  2019-08-22       Impact factor: 5.118

5.  Multiple New Strains of Amphidomataceae (Dinophyceae) from the North Atlantic Revealed a High Toxin Profile Variability of Azadinium spinosum and a New Non-Toxigenic Az. cf. spinosum.

Authors:  Urban Tillmann; Stephan Wietkamp; Haifeng Gu; Bernd Krock; Rafael Salas; Dave Clarke
Journal:  Microorganisms       Date:  2021-01-08

6.  Structure Elucidation and in Vitro Toxicity of New Azaspiracids Isolated from the Marine Dinoflagellate Azadinium poporum.

Authors:  Bernd Krock; Urban Tillmann; Éric Potvin; Hae Jin Jeong; Wolfgang Drebing; Jane Kilcoyne; Ahmed Al-Jorani; Michael J Twiner; Qun Göthel; Matthias Köck
Journal:  Mar Drugs       Date:  2015-10-30       Impact factor: 5.118

7.  Discovery of chitin in skeletons of non-verongiid Red Sea demosponges.

Authors:  Hermann Ehrlich; Lamiaa A Shaala; Diaa T A Youssef; Sonia Żółtowska-Aksamitowska; Mikhail Tsurkan; Roberta Galli; Heike Meissner; Marcin Wysokowski; Iaroslav Petrenko; Konstantin R Tabachnick; Viatcheslav N Ivanenko; Nicole Bechmann; Yvonne Joseph; Teofil Jesionowski
Journal:  PLoS One       Date:  2018-05-15       Impact factor: 3.240
  7 in total

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