| Literature DB >> 19232820 |
Min Ji An1, Jae Hee Cheon, Seung Won Kim, Eun Soo Kim, Tae Il Kim, Won Ho Kim.
Abstract
The plant sterol guggulsterone has recently been shown to have anti-tumorigenic potential. This study was designed to investigate the anti-tumor efficacy of guggulsterone and to elucidate its molecular mechanisms in colon cancer. Guggulsterone significantly increased apoptosis in HT-29 cells by activating caspases-3 and -8. Furthermore, guggulsterone decreased cIAP-1, cIAP-2, and Bcl-2 levels and increased the levels of truncated Bid, Fas, p-JNK, and p-c-Jun. The size of HT-29 xenograft tumors in guggulsterone-treated mice was significantly smaller than of the size of tumors in control mice. The present study suggests a potential therapeutic use for this compound in the treatment of colorectal cancer.Entities:
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Year: 2009 PMID： 19232820 DOI： 10.1016/j.canlet.2009.01.026
Source DB: PubMed Journal: Cancer Lett ISSN： 0304-3835 Impact factor: 8.679