| Literature DB >> 19232500 |
Akhil Maheshwari1, Nikolai N Voitenok, Svetlana Akalovich, Sadiq S Shaik, David A Randolph, Brian Sims, Rakesh P Patel, Cheryl R Killingsworth, Michael B Fallon, Robin K Ohls.
Abstract
Interleukin-8 (IL-8/CXCL8) is widely expressed in fetal tissues although inflammatory changes are not seen. Circulating IL-8 is comprised of an endothelial-derived [ala-IL-8](77) isoform and another, more potent [ser-IL-8](72) secreted by most other cells; [ala-IL-8](77) can be converted into [ser-IL-8](72) by proteolytic removal of an N-terminal pentapeptide from [ala-IL-8](77). In this study, we show [ala-IL-8](77) is the predominant circulating isoform of IL-8 in premature neonates but not in term neonates/adults, who have [ser-IL-8](72) as the major isoform. This isoform switch from the less potent [ala-IL-8](77) to [ser-IL-8](72) correlates with a maturational increase in the neutrophil chemotactic potency of plasma IL-8. The emergence of [ser-IL-8](72) as the major isoform is likely due to increased plasma [ala-IL-8](77)-convertase activity and/or changes in the cellular sources of IL-8. Developmental changes in IL-8 isoforms may serve to minimize its inflammatory effects in the fetus and also provide a mechanism to restore its full activity after birth.Entities:
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Year: 2009 PMID： 19232500 PMCID： PMC2757161 DOI： 10.1016/j.cyto.2008.12.022
Source DB: PubMed Journal: Cytokine ISSN： 1043-4666 Impact factor: 3.861