| Literature DB >> 19231823 |
Rizia Bardhan1, Nathaniel K Grady, Joseph R Cole, Amit Joshi, Naomi J Halas.
Abstract
Metallic nanoparticles influence the quantum yield and lifetime of adjacent fluorophores in a manner dependent on the properties of the nanostructure. Here we directly compare the fluorescence enhancement of the near-infrared fluorophore IR800 by Au nanoshells (NSs) and Au nanorods (NRs), where human serum albumin (HSA) serves as a spacer layer between the nanoparticle and the fluorophore. Our measurements reveal that the quantum yield of IR800 is enhanced from approximately 7% as an isolated fluorophore to 86% in a NSs-HSA-IR800 complex and 74% in a NRs-HSA-IR800 complex. This dramatic increase in fluorescence shows tremendous potential for contrast enhancement in fluorescence-based bioimaging.Entities:
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Year: 2009 PMID： 19231823 DOI： 10.1021/nn900001q
Source DB: PubMed Journal: ACS Nano ISSN： 1936-0851 Impact factor: 15.881