PURPOSE: To date, the therapy of bisphosphonate-associated osteonecrosis of the jaws (BONJ) has been hampered by the lack of imaging modalities that enable the extent of necrosis to be visualized. This study aims to demonstrate the feasibility of tetracycline fluorescence guided bone resection in the surgical management of BONJ. PATIENTS AND METHODS: Following a 10-day preoperative administration of doxycycline in patients suffering from BONJ, sufficient doxycycline is incorporated into viable bone to be visualized with a certified medical lamp emitting exciting light at 400 to 460 nm. RESULTS: Viable and necrotic bone can be discriminated intraoperatively in a routine and reproducible manner by doxycycline bone fluorescence. CONCLUSION: In the therapy of BONJ, conservative concepts are to be favored. The fact that necrotic bone can now be selectively resected signifies an improvement of the conservative surgical therapy of BONJ.
PURPOSE: To date, the therapy of bisphosphonate-associated osteonecrosis of the jaws (BONJ) has been hampered by the lack of imaging modalities that enable the extent of necrosis to be visualized. This study aims to demonstrate the feasibility of tetracycline fluorescence guided bone resection in the surgical management of BONJ. PATIENTS AND METHODS: Following a 10-day preoperative administration of doxycycline in patients suffering from BONJ, sufficient doxycycline is incorporated into viable bone to be visualized with a certified medical lamp emitting exciting light at 400 to 460 nm. RESULTS: Viable and necrotic bone can be discriminated intraoperatively in a routine and reproducible manner by doxycycline bone fluorescence. CONCLUSION: In the therapy of BONJ, conservative concepts are to be favored. The fact that necrotic bone can now be selectively resected signifies an improvement of the conservative surgical therapy of BONJ.
Authors: Christoph Pautke; Stephan Vogt; Kilian Kreutzer; Cornelia Haczek; Gabriele Wexel; Andreas Kolk; Andreas B Imhoff; Horst Zitzelsberger; Stefan Milz; Thomas Tischer Journal: J Anat Date: 2010-04-26 Impact factor: 2.610
Authors: Thomas Mücke; Janett Koschinski; Herbert Deppe; Stefan Wagenpfeil; Christoph Pautke; David A Mitchell; Klaus-Dietrich Wolff; Frank Hölzle Journal: J Cancer Res Clin Oncol Date: 2010-10-07 Impact factor: 4.553
Authors: Victoria Rollason; Alexandra Laverrière; Laura C I MacDonald; Tanya Walsh; Martin R Tramèr; Nicole B Vogt-Ferrier Journal: Cochrane Database Syst Rev Date: 2016-02-26
Authors: D Yoshiga; M Sasaguri; K Matsuo; S Kokuryou; M Habu; M Oda; M Kodama; H Tsurushima; O Sakaguchi; T Sakurai; J Tanaka; Y Morimoto; I Yoshioka; K Tominaga Journal: Osteoporos Int Date: 2015-06-03 Impact factor: 4.507