| Literature DB >> 19230834 |
Vikas Kumar1, Nailya Kitaeff, Mark B Hampton, Mark B Cannell, Christine C Winterbourn.
Abstract
Peroxiredoxins decompose peroxides through reversible oxidation of their active site cysteines. The redox state of the 2-Cys peroxiredoxins, 1, 2 and 3, was investigated in mouse hearts undergoing ischemia and reperfusion in a Langendorff system. The peroxiredoxins were predominantly reduced in control hearts. Mitochondrial peroxiredoxin 3 underwent significant oxidation to its disulfide-linked dimer during ischemia. Oxidation was largely reversed during reperfusion. No redox changes in cytoplasmic peroxiredoxins 1 and 2 were apparent. Peroxiredoxin 3 oxidation suggests localized mitochondrial generation of reactive oxidants during ischemia. This local antioxidant activity of peroxiredoxin 3 may have a role in maintaining cardiac function.Entities:
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Year: 2009 PMID： 19230834 DOI： 10.1016/j.febslet.2009.02.018
Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124