Jian-Qun Liu1, Ji-Mei Wu, Xiao-Li Kou, Qin Hong. 1. Key Laboratory of Modern Preparation of TCM, Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China. liu5308@sina.com
Abstract
OBJECTIVE: To investigate the chemical constituents of Grewia biloba and find its bioactive compounds. METHODS: Compounds were isolated by silica gel, MCI, Sephadex LH-20 and Rp-18 column chromatography, and purified by recrystallization. Their structures were elucidated by spectral analysis and other methods. RESULTS: Six compounds were isolated and identified as friedelin (1) epi-friedelan-3-ol (2), heneicosanoic acid (3), beta-sitosterol (4), Propyl palmitate (5), eatechin (6), respectively. CONCLUSION: Compounds 1-3, 5, 6 are isolated from Grewia genus for the first time and compounds 4 is isolated from Grewia biloba for the first time.
OBJECTIVE: To investigate the chemical constituents of Grewia biloba and find its bioactive compounds. METHODS: Compounds were isolated by silica gel, MCI, Sephadex LH-20 and Rp-18 column chromatography, and purified by recrystallization. Their structures were elucidated by spectral analysis and other methods. RESULTS: Six compounds were isolated and identified as friedelin (1) epi-friedelan-3-ol (2), heneicosanoic acid (3), beta-sitosterol (4), Propyl palmitate (5), eatechin (6), respectively. CONCLUSION: Compounds 1-3, 5, 6 are isolated from Grewia genus for the first time and compounds 4 is isolated from Grewia biloba for the first time.
Authors: Wasim Ul Bari; Mohammad Zahoor; Alam Zeb; Muhammad Umar Khayam Sahibzada; Riaz Ullah; Abdelaaty A Shahat; Hafiz Majid Mahmood; Irfan Khan Journal: Drug Des Devel Ther Date: 2019-08-26 Impact factor: 4.162