Effect on diurnal intraocular pressure of the fixed combination of latanoprost 0.005% and timolol 0.5% administered in the evening in glaucoma.

We evaluated the efficacy of fixed combination of 0.005% latanoprost and 0.5% timolol maleate administered once daily in the evening for treating glaucoma patients. This combination proved an effective alternative to achieve an additional intraocular pressure IOP lowering effect in patients treated with either drug alone and as an alterative in patients treated with unfixed combination of latanoprost and timolol and optimal IOP control.