| Literature DB >> 1922954 |
T Yamaguchi1, Y Kuraishi, M Minami, S Nakai, Y Hirai, M Satoh.
Abstract
The effect of methamphetamine on the expression of interleukin-1 beta (IL-1 beta) mRNA in the rat brain was investigated with Northern blot analysis. Methamphetamine (2-15 mg/kg, i.p.) caused a marked induction of IL-1 beta mRNA in the hypothalamus among the 8 brain regions examined, in a dose-dependent manner. The level of IL-1 beta mRNA reached a maximum at 1 h and rapidly declined within 2 h after the injection of 15 mg/kg. These results provide the first evidence that methamphetamine induces the expression of IL-1 beta mRNA in the hypothalamus, which may be partly involved in the production of central actions of this drug.Entities:
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Year: 1991 PMID： 1922954 DOI： 10.1016/0304-3940(91)90766-m
Source DB: PubMed Journal: Neurosci Lett ISSN： 0304-3940 Impact factor: 3.046