Literature DB >> 1922940

Exact cleavage site of Alzheimer amyloid precursor in neuronal PC-12 cells.

J P Anderson1, F S Esch, P S Keim, K Sambamurti, I Lieberburg, N K Robakis.   

Abstract

We have identified the secretory cleavage site in the Alzheimer amyloid precursor (APP) in a non-transfected neuronal cell line, using cyanogen bromide digests of APP purified from medium conditioned by PC-12 cells which were differentiated to a neuronal phenotype. The results obtained are most consistent with proteolysis of the Lys16-Leu17 bond in the beta amyloid peptide, followed by partial removal of Lys16 by a basic carboxypeptidase.

Entities:  

Mesh：

Substances：

Year:  1991        PMID： 1922940     DOI： 10.1016/0304-3940(91)90775-o

Source DB:  PubMed          Journal:  Neurosci Lett        ISSN： 0304-3940            Impact factor:   3.046


  39 in total

1.  Epitope and isotype specificities of antibodies to beta -amyloid peptide for protection against Alzheimer's disease-like neuropathology.

Authors:  Frédérique Bard; Robin Barbour; Catherine Cannon; Robert Carretto; Michael Fox; Dora Games; Teresa Guido; Kathleen Hoenow; Kang Hu; Kelly Johnson-Wood; Karen Khan; Dora Kholodenko; Celeste Lee; Mike Lee; Ruth Motter; Minh Nguyen; Amanda Reed; Dale Schenk; Pearl Tang; Nicki Vasquez; Peter Seubert; Ted Yednock
Journal:  Proc Natl Acad Sci U S A       Date:  2003-02-03       Impact factor: 11.205

Review 2.  Amyloidosis in aging and Alzheimer's disease.

Authors:  D L Price; L C Walker; L J Martin; S S Sisodia
Journal:  Am J Pathol       Date:  1992-10       Impact factor: 4.307

Review 3.  Cellular mechanisms of γ-secretase substrate selection, processing and toxicity.

Authors:  Gael Barthet; Anastasios Georgakopoulos; Nikolaos K Robakis
Journal:  Prog Neurobiol       Date:  2012-05-20       Impact factor: 11.685

4.  Formation of Pmel17 amyloid is regulated by juxtamembrane metalloproteinase cleavage, and the resulting C-terminal fragment is a substrate for gamma-secretase.

Authors:  Markus P Kummer; Hiroko Maruyama; Claudia Huelsmann; Sandra Baches; Sascha Weggen; Edward H Koo
Journal:  J Biol Chem       Date:  2008-12-01       Impact factor: 5.157

5.  Transcriptome profiling of neuronal model cell PC12 from rat pheochromocytoma.

Authors:  Ramasamy Saminathan; Arjunan Pachiappan; Luo Feng; Edward G Rowan; Ponnampalam Gopalakrishnakone
Journal:  Cell Mol Neurobiol       Date:  2009-02-05       Impact factor: 5.046

Review 6.  Beta-secretase: structure, function, and evolution.

Authors:  Chitra Venugopal; Christina M Demos; K S Jagannatha Rao; Miguel A Pappolla; Kumar Sambamurti
Journal:  CNS Neurol Disord Drug Targets       Date:  2008-06       Impact factor: 4.388

7.  Melatonin prevents death of neuroblastoma cells exposed to the Alzheimer amyloid peptide.

Authors:  M A Pappolla; M Sos; R A Omar; R J Bick; D L Hickson-Bick; R J Reiter; S Efthimiopoulos; N K Robakis
Journal:  J Neurosci       Date:  1997-03-01       Impact factor: 6.167

Review 8.  Membrane protein secretases.

Authors:  N M Hooper; E H Karran; A J Turner
Journal:  Biochem J       Date:  1997-01-15       Impact factor: 3.857

9.  Secretory processing of amyloid precursor protein is inhibited by increase in cellular cholesterol content.

Authors:  M Racchi; R Baetta; N Salvietti; P Ianna; G Franceschini; R Paoletti; R Fumagalli; S Govoni; M Trabucchi; M Soma
Journal:  Biochem J       Date:  1997-03-15       Impact factor: 3.857

10.  Amyloid precursor protein compartmentalization restricts beta-amyloid production: therapeutic targets based on BACE compartmentalization.

Authors:  Swetal Gandhi; Lorenzo M Refolo; Kumar Sambamurti
Journal:  J Mol Neurosci       Date:  2004       Impact factor: 3.444
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.