| Literature DB >> 19229242 |
Asya Rolls1, Ravid Shechter, Michal Schwartz.
Abstract
Following CNS injury, in an apparently counterintuitive response, scar tissue formation inhibits axonal growth, imposing a major barrier to regeneration. Accordingly, scar-modulating treatments have become a leading therapeutic goal in the field of spinal cord injury. However, increasing evidence suggests a beneficial role for this scar tissue as part of the endogenous local immune regulation and repair process. How can these opposing effects be reconciled? Perhaps it is all a matter of timing.Entities:
Mesh：
Substances：
Year: 2009 PMID： 19229242 DOI： 10.1038/nrn2591
Source DB: PubMed Journal: Nat Rev Neurosci ISSN： 1471-003X Impact factor: 34.870