BACKGROUND: Recent findings suggest that patients with behavioural variant frontotemporal dementia (bv-FTD) differ in their disease progression (progressive vs non-progressive patients). The current study investigates whether the two groups can be discriminated by their clinical features at first presentation. METHODS: Archival clinical data of the Early Onset Dementia Clinic, Cambridge, UK, were analysed for 71 patients with bv-FTD: 45 progressive and 26 non-progressive cases with more than 3 years of follow-up. RESULTS: The subgroups were largely indistinguishable on the basis of the presenting clinical features but could be distinguished on general cognitive (Addenbrooke's Cognitive Examination-revised) and selected supportive diagnostic features (distractibility, stereotypic speech, impaired activities of daily living (ADLs) and current depression). CONCLUSIONS: Progressive and non-progressive patients are difficult to differentiate on the basis of current clinical diagnostic criteria for FTD but a combination of general cognitive, executive dysfunction and impaired ADL measures appear to be the most promising discriminators.
BACKGROUND: Recent findings suggest that patients with behavioural variant frontotemporal dementia (bv-FTD) differ in their disease progression (progressive vs non-progressive patients). The current study investigates whether the two groups can be discriminated by their clinical features at first presentation. METHODS: Archival clinical data of the Early Onset Dementia Clinic, Cambridge, UK, were analysed for 71 patients with bv-FTD: 45 progressive and 26 non-progressive cases with more than 3 years of follow-up. RESULTS: The subgroups were largely indistinguishable on the basis of the presenting clinical features but could be distinguished on general cognitive (Addenbrooke's Cognitive Examination-revised) and selected supportive diagnostic features (distractibility, stereotypic speech, impaired activities of daily living (ADLs) and current depression). CONCLUSIONS: Progressive and non-progressive patients are difficult to differentiate on the basis of current clinical diagnostic criteria for FTD but a combination of general cognitive, executive dysfunction and impaired ADL measures appear to be the most promising discriminators.
Authors: Baber K Khan; Jennifer S Yokoyama; Leonel T Takada; Sharon J Sha; Nicola J Rutherford; Jamie C Fong; Anna M Karydas; Teresa Wu; Robin S Ketelle; Matthew C Baker; Mariely-Dejesus Hernandez; Giovanni Coppola; Daniel H Geschwind; Rosa Rademakers; Suzee E Lee; Howard J Rosen; Gil D Rabinovici; William W Seeley; Katherine P Rankin; Adam L Boxer; Bruce L Miller Journal: J Neurol Neurosurg Psychiatry Date: 2012-04 Impact factor: 10.154
Authors: Suzee E Lee; Anna M Khazenzon; Andrew J Trujillo; Christine C Guo; Jennifer S Yokoyama; Sharon J Sha; Leonel T Takada; Anna M Karydas; Nikolas R Block; Giovanni Coppola; Mochtar Pribadi; Daniel H Geschwind; Rosa Rademakers; Jamie C Fong; Michael W Weiner; Adam L Boxer; Joel H Kramer; Howard J Rosen; Bruce L Miller; William W Seeley Journal: Brain Date: 2014-10-01 Impact factor: 13.501