Seung Woo Han1, Won Ki Lee, Ki Tae Kwon, Byung Ki Lee, Eon Jeong Nam, Gun Woo Kim. 1. The Center of Rheumatology, Department of Internal Medicine, Daegu Fatima Hospital, and Department of Preventive Medicine, Kyungpook National University School of Medicine, 576-13, Sinam 4 dong, Donggu, Daegu, 701-010, Republic of Korea.
Abstract
OBJECTIVE: We investigated potential associations between rheumatoid arthritis (RA) and interferon regulatory factor 5 (IRF5) polymorphisms in a metaanalysis. METHODS: This metaanalysis included 5 case-control studies, which provided a total of 6582 RA cases and 5375 controls. Odds ratios (OR) were employed to evaluate the risk of RA according to the 4 single-nucleotide polymorphisms (SNP) in IRF5 (rs729302, rs2004640, rs752637, and rs2280714) and data were analyzed in respect to association between alleles. RESULTS: Among 4 candidate SNP, rs729302, rs2004640, and rs2280714 were statistically significant; both allele C of rs729302 and allele G of rs2004640 within the promoter region of IRF5 were associated with a protective effect [random-effects (RE) OR 0.889, 95% confidence interval (CI) 0.803-0.977, p=0.015 for rs729302; and RE OR 0.905, 95% CI 0.848-0.965, p=0.002 for rs2004640]. Similar results were also obtained in T allele of rs2280714 in the 3'-untranslated region (RE OR 0.927, 95% CI 0.866-0.992, p=0.029). There was no evidence of publication bias from funnel-plot asymmetry and Egger's regression test. CONCLUSION: Our metaanalysis supported the evidence of the significant role of IRF5 polymorphisms in RA.
OBJECTIVE: We investigated potential associations between rheumatoid arthritis (RA) and interferon regulatory factor 5 (IRF5) polymorphisms in a metaanalysis. METHODS: This metaanalysis included 5 case-control studies, which provided a total of 6582 RA cases and 5375 controls. Odds ratios (OR) were employed to evaluate the risk of RA according to the 4 single-nucleotide polymorphisms (SNP) in IRF5 (rs729302, rs2004640, rs752637, and rs2280714) and data were analyzed in respect to association between alleles. RESULTS: Among 4 candidate SNP, rs729302, rs2004640, and rs2280714 were statistically significant; both allele C of rs729302 and allele G of rs2004640 within the promoter region of IRF5 were associated with a protective effect [random-effects (RE) OR 0.889, 95% confidence interval (CI) 0.803-0.977, p=0.015 for rs729302; and RE OR 0.905, 95% CI 0.848-0.965, p=0.002 for rs2004640]. Similar results were also obtained in T allele of rs2280714 in the 3'-untranslated region (RE OR 0.927, 95% CI 0.866-0.992, p=0.029). There was no evidence of publication bias from funnel-plot asymmetry and Egger's regression test. CONCLUSION: Our metaanalysis supported the evidence of the significant role of IRF5 polymorphisms in RA.
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