Time course of the redox state potential of the cerebral cortex, developing as a reaction to implanted platinum electrodes.

The time course of the redox-state potential of the brain (ROSP) of the brain was investigated in five series of chronic experiments in rabbits with different numbers of electrodes (8-12, 22-25, 50) implanted to the level of the dura mater, with 10-12 electrodes implanted to the level of the pia mater, and with four to eight pairs of electrodes implanted in the cortical layer to a distance of 1.5-2 mm. It was found that the ROSP undergoes a number of fluctuations in the negative and positive directions with a gradually decreasing amplitude in the course of 5-25 days following the operation, after which relatively stable negative values of the ROSP are established on the average in electrodes implanted to the level of the dura mater, and positive values in electrodes implanted to the level of the pia mater.