Literature DB >> 19226500

Design, synthesis, and biological evaluation of levoglucosenone-derived ras activation inhibitors.

Christian Müller1, Maria Antonia Gomez-Zurita Frau, Dario Ballinari, Sonia Colombo, Alessandro Bitto, Enzo Martegani, Cristina Airoldi, Anske Stephanie van Neuren, Matthias Stein, Jörg Weiser, Carlo Battistini, Francesco Peri.   

Abstract

A panel of new potential Ras ligands was generated by decorating a tricyclic levoglucosenone-derived scaffold with aromatic moieties. Some members of the panel show in vitro inhibitory activity toward the nucleotide exchange process on Ras and are toxic to some human cancer cell lines.

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Year:  2009        PMID： 19226500     DOI： 10.1002/cmdc.200800416

Source DB:  PubMed          Journal:  ChemMedChem        ISSN： 1860-7179            Impact factor:   3.466


  3 in total

1.  Glycomimetic Based Approach toward Selective Carbonic Anhydrase Inhibitors.

Authors:  Debora Pratesi; Camilla Matassini; Andrea Goti; Andrea Angeli; Fabrizio Carta; Claudiu T Supuran; Rolando Spanevello; Francesca Cardona
Journal:  ACS Med Chem Lett       Date:  2020-03-11       Impact factor: 4.345

Review 2.  Levoglucosenone: Bio-Based Platform for Drug Discovery.

Authors:  Jason E Camp; Ben W Greatrex
Journal:  Front Chem       Date:  2022-05-31       Impact factor: 5.545

3.  Antineoplastic activity of products derived from cellulose-containing materials: levoglucosenone and structurally-related derivatives as new alternatives for breast cancer treatment.

Authors:  Damian Ignacio Delbart; German Francisco Giri; Agostina Cammarata; Melisan Denise Pan; Lizeth Ariza Bareño; Natalia Loreley Amigo; Andrés Bechis; Alejandra Graciela Suarez; Rolando Ángel Spanevello; Marcela Solange Villaverde; Laura Beatriz Todaro; Alejandro Jorge Urtreger
Journal:  Invest New Drugs       Date:  2021-09-03       Impact factor: 3.850
  3 in total

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